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Ac4GlcNAlk is a metabolic chemical reporter (MCR) for studying cell surface glycosylation. It is used for identification of O-GlcNAc modified proteins. In cells expressing the engineered pyrophosphorylase, mut-AGX1, Ac4GlcNAlk is efficiently converted into UDP-GlcNAlk which is incorporated into GlcNAlk-containing glycoproteins.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 427.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.7 mL||23.4 mL|
|5 mM||0.47 mL||2.34 mL||4.68 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
Cioce et al (2021) Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase. ACS Chem.Biol. 16 1961 PMID: 33835779
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Keywords: Ac4GlcNAlk, Ac4GlcNAlk supplier, bio-orthogonal, glycosylation, glycoproteins, probes, labeling, labelling, metabolic, chemical, reporter, MCR, O-GlcNAc, Glycobiology, Probes, Post-translational, Modifications, 7750, Tocris Bioscience
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