NSC 624206

Pricing Availability Delivery Time Qty
Cat.No. 4993 - NSC 624206 | C19H32ClNS2.HCl | CAS No. 13116-77-3
Description: Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name: N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.

Technical Data

M. Wt 410.51
Formula C19H32ClNS2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 13116-77-3
PubChem ID 361263
InChI Key JQHUAYXPNPTQRO-UHFFFAOYSA-N
Smiles ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.53 50
ethanol 8.21 20

Preparing Stock Solutions

The following data is based on the product molecular weight 410.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References

References are publications that support the products' biological activity.

Ungermannova et al (2012) Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 17 421 PMID: 22274912


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Keywords: NSC 624206, supplier, NSC624206, tumour, suppressor, protein, p27, ubiquitination, thioesterformation, adenylation, ubiquitin-activating, enzymes, E1, inhibitors, inhibits, Ubiquitin-activating, Enzyme, E1, Tocris Bioscience

Citations for NSC 624206

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