NSC 624206

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Description: Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name: N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for NSC 624206

NSC 624206 is an ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.

Technical Data for NSC 624206

M. Wt 410.51
Formula C19H32ClNS2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 13116-77-3
PubChem ID 361263

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 624206

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.53 50
ethanol 8.21 20

Preparing Stock Solutions for NSC 624206

The following data is based on the product molecular weight 410.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.87 mL 24.36 mL 48.72 mL
2.5 mM 0.97 mL 4.87 mL 9.74 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
25 mM 0.1 mL 0.49 mL 0.97 mL

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References for NSC 624206

References are publications that support the biological activity of the product.

Ungermannova et al (2012) Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 17 421 PMID: 22274912

If you know of a relevant reference for NSC 624206, please let us know.

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Keywords: NSC 624206, NSC 624206 supplier, NSC624206, tumour, suppressor, protein, p27, ubiquitination, thioesterformation, adenylation, ubiquitin-activating, enzymes, E1, inhibitors, inhibits, Ubiquitin-activating, Enzyme, Post-translational, Modifications, 4993, Tocris Bioscience

Citations for NSC 624206

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Autophagy Scientific Review

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.