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Pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC50 = 2.12μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.27 mL||32.54 mL|
|5 mM||0.65 mL||3.25 mL||6.51 mL|
|10 mM||0.33 mL||1.63 mL||3.25 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the biological activity of the product.
Shakya et al (2018) Update on Nitazoxanide: a multifunctional chemotherapeutic agent. Curr.Drug Discov.Technol. 15 201 PMID: 28748751
Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30 269 PMID: 32020029
Qu et al (2017) Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat.Chem.Biol. 14 94 PMID: 29083417
If you know of a relevant reference for Nitazoxanide, please let us know.
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Keywords: Nitazoxanide, Nitazoxanide supplier, broad, spectrum, anti-infective, antiparasitic, antiviral, inhibitors, inhibits, pyruvate, flavodoxin/ferredoxin, oxidoreductase, PFOR, peptidyl, arginine, deiminase, 2, PADI2, PAD2, SARS-CoV-2, Wnt, signaling, Other, Oxygenases/Oxidases, Post-translational, Modifications, Signaling, Non-selective, Antivirals, 7234, Tocris Bioscience
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