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Description: Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective
Chemical Name: 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity for Nitazoxanide

Nitazoxanide is a pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC50 = 2.12μM).

Compound Libraries for Nitazoxanide

Nitazoxanide is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Nitazoxanide

M. Wt 307.28
Formula C12H9N3O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 55981-09-4
PubChem ID 41684
Smiles CC(OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nitazoxanide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.73 100

Preparing Stock Solutions for Nitazoxanide

The following data is based on the product molecular weight 307.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References for Nitazoxanide

References are publications that support the biological activity of the product.

Shakya et al (2018) Update on Nitazoxanide: a multifunctional chemotherapeutic agent. Curr.Drug Discov.Technol. 15 201 PMID: 28748751

Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30 269 PMID: 32020029

Qu et al (2017) Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat.Chem.Biol. 14 94 PMID: 29083417

If you know of a relevant reference for Nitazoxanide, please let us know.

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Citations for Nitazoxanide

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