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Description: Alkyne containing monosaccharide building block; used in BOCTAG
Chemical Name: 2-Deoxy-2-[(1-oxo-5-hexyn-1-yl)amino]-D-galactopyranose-1,3,4,6-tetraacetate
Purity: ≥95% (HPLC)

Biological Activity for Ac4GalN6yne

Ac4GalN6yne is a cell-permeable alkyne-containing monosaccharide building block. It can be used in Bio-Orthogonal Cell-specific Tagging of Glycoproteins (BOCTAG) technique. In this strategy, cells carrying an artificial biosynthetic pathway (B. longum NahK and mut-AGX1) can generate alkyne-tagged UDP-GalN6yne, that are then used by glycosyltransferases to chemically tag the glycoproteome. Ac4GalN6yne can be used for bioorthogonal labelling in vitro and mouse models.

Technical Data for Ac4GalN6yne

M. Wt 441.43
Formula C20H27NO10
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(N[C@@H]1[C@H]([C@H]([C@H](OC1OC(C)=O)COC(C)=O)OC(C)=O)OC(C)=O)CCCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ac4GalN6yne

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.83 20 with gentle warming

Preparing Stock Solutions for Ac4GalN6yne

The following data is based on the product molecular weight 441.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.33 mL 56.63 mL 113.27 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
2 mM 1.13 mL 5.66 mL 11.33 mL
10 mM 0.23 mL 1.13 mL 2.27 mL

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References for Ac4GalN6yne

References are publications that support the biological activity of the product.

Cioce et al (2022) Cell-specific bioorthogonal tagging of glycoproteins. Nat.Commun. 13 6237 PMID: 36284108

If you know of a relevant reference for Ac4GalN6yne, please let us know.

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Citations for Ac4GalN6yne

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