AMBMP hydrochloride

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Cat.No. 6043 - AMBMP hydrochloride | C19H18N4O3.HCl | CAS No. 2095432-75-8
Description: Wnt canonical signaling activator; also tubulin polymerization inhibitor
Alternative Names: BML 284, CID 11210285
Chemical Name: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.

Technical Data

M. Wt 386.84
Formula C19H18N4O3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2095432-75-8
PubChem ID 122705993
InChI Key XZOFNDFDGVAIEH-UHFFFAOYSA-N
Smiles COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 386.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.93 mL 25.85 mL
5 mM 0.52 mL 2.59 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References

References are publications that support the biological activity of the product.

Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987 PMID: 15724259

Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61 PMID: 26613980

Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9 PMID: 27207629

Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266 PMID: 23405280


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Citations for AMBMP hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for AMBMP hydrochloride

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.