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Biological Activity for AMBMP hydrochloride
AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.
Technical Data for AMBMP hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AMBMP hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AMBMP hydrochloride
The following data is based on the product molecular weight 386.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.59 mL||12.93 mL||25.85 mL|
|5 mM||0.52 mL||2.59 mL||5.17 mL|
|10 mM||0.26 mL||1.29 mL||2.59 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
Product Datasheets for AMBMP hydrochloride
References for AMBMP hydrochloride
References are publications that support the biological activity of the product.
Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987 PMID: 15724259
Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61 PMID: 26613980
Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9 PMID: 27207629
Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266 PMID: 23405280
If you know of a relevant reference for AMBMP hydrochloride, please let us know.
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Keywords: AMBMP hydrochloride, AMBMP hydrochloride supplier, BML284, CID11210285, wnt, canonical, signaling, pathway, activators, activates, tublulin, polymerization, inhibitors, inhibits, BML, 284, CID, 11210285, Other, Wnt, Signaling, Microtubules, 6043, Tocris Bioscience
1 Citation for AMBMP hydrochloride
Citations are publications that use Tocris products. Selected citations for AMBMP hydrochloride include:
Vadivel et al (2020) SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. Biochem J 477 1409-1425 PMID: 32219372
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Literature in this Area
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