Docetaxel

Pricing Availability Delivery Time Qty
Cat.No. 4056 - Docetaxel | C43H53NO14 | CAS No. 114977-28-5
Description: Microtubule stabilizer
Chemical Name: [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Technical Data

M. Wt 807.88
Formula C43H53NO14
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 114977-28-5
PubChem ID 148124
InChI Key ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Smiles O[C@@H]1C4=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C[C@@](C(C)4C)(O)[C@@H](OC(C6=CC=CC=C6)=O)[C@@]([C@@]3(OC(C)=O)[C@H](OC3)C[C@@H]2O)([H])[C@]2(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 80.79 100
ethanol 80.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 807.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.19 mL 12.38 mL
5 mM 0.25 mL 1.24 mL 2.48 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lyseng-Williamson and Fenton (2005) Docetaxel: a review of its use in metastatic breast cancer. Drugs 65 2513 PMID: 16296875

Ramaswamy and Puhalla (2006) Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc) 42 265 PMID: 16703123


If you know of a relevant reference for Docetaxel, please let us know.

View Related Products by Target

Keywords: Docetaxel, supplier, cancer, therapy, antitumor, binds, stabilizes, microtubules, microtubule, stabilizers, chemotherapeutics, Microtubules, Microtubules, Tocris Bioscience

1 Citation for Docetaxel

Citations are publications that use Tocris products. Selected citations for Docetaxel include:

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007


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Reviews for Docetaxel

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Literature in this Area

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