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Biological Activity for Docetaxel
Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.
Compound Libraries for Docetaxel
Technical Data for Docetaxel
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Docetaxel
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Docetaxel
The following data is based on the product molecular weight 807.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.24 mL||6.19 mL||12.38 mL|
|5 mM||0.25 mL||1.24 mL||2.48 mL|
|10 mM||0.12 mL||0.62 mL||1.24 mL|
|50 mM||0.02 mL||0.12 mL||0.25 mL|
References for Docetaxel
References are publications that support the biological activity of the product.
Lyseng-Williamson and Fenton (2005) Docetaxel: a review of its use in metastatic breast cancer. Drugs 65 2513 PMID: 16296875
Ramaswamy and Puhalla (2006) Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc) 42 265 PMID: 16703123
If you know of a relevant reference for Docetaxel, please let us know.
Keywords: Docetaxel, Docetaxel supplier, cancer, therapy, antitumor, binds, stabilizes, microtubules, microtubule, stabilizers, chemotherapeutics, Microtubules, 4056, Tocris Bioscience
10 Citations for Docetaxel
Citations are publications that use Tocris products. Selected citations for Docetaxel include:
Kathawala et al (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther 13 714 PMID: 24431074
Karmen et al (2016) Antitumor activity of amidino-substituted benzimidazole and benzimidazo[1,2-a]quinoline derivatives tested in 2D and 3D cell culture systems. J Enzyme Inhib Med Chem 31 1139-45 PMID: 26505692
Mabe et al (2018) Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest 128 4413 PMID: 30148456
Hui et al (2017) Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer. Oncotarget 8 103744-103757 PMID: 29262597
Malin et al (2017) A high-content image analysis approach for quantitative measurements of chemosensitivity in patient-derived tumor microtissues. Sci Rep 7 6600 PMID: 28747710
Bonifacio Nicolás et al (2023) Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer. Int J Biol Sci 19 1731-1747 PMID: 37063429
Leslie V et al (2019) CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death. Cancer Cell Int 19 26 PMID: 30740034
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Geoffrey et al (2020) Retinoic acid receptor γ is a therapeutically targetable driver of growth and survival in prostate cancer. Cancer Rep (Hoboken) 3 e1284 PMID: 32881426
Do you know of a great paper that uses Docetaxel from Tocris? Please let us know.
Reviews for Docetaxel
Average Rating: 5 (Based on 1 Review.)
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Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets