CMPD-1

Pricing Availability Delivery Time Qty
Cat.No. 2186 - CMPD-1 | C22H20FNO2 | CAS No. 41179-33-3
Description: Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

Compound Libraries

CMPD-1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 349.4
Formula C22H20FNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 41179-33-3
PubChem ID 11382492
InChI Key ODYAQBDIXCVKAE-UHFFFAOYSA-N
Smiles OC1=CC=C(NC(=O)CCCC2=CC=C(C=C2)C2=CC=CC=C2F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.94 100
ethanol 34.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 349.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Davidson et al (2004) Discovery and characterisation of a substrate selective p38α inhibitor. Biochemistry 43 11658 PMID: 15362850

Gurgis et al (2015) Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discovery 1 15028 PMID:


If you know of a relevant reference for CMPD-1, please let us know.

View Related Products by Product Action

View all p38 MAPK Inhibitors

Keywords: CMPD-1, supplier, Non-ATP-competitive, p38α, p38alpha, inhibitors, inhibits, Mitogen-Activated, Protein, Kinase, p38, MAPK, Kinases, Signaling, Signalling, p38, Microtubules, MK2, p38, Tocris Bioscience

1 Citation for CMPD-1

Citations are publications that use Tocris products. Selected citations for CMPD-1 include:

Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705


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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for CMPD-1

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.