New Products

View all New Products Alphabetically

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

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Cat. No. Product Name / Activity Date Added
6774 16673-34-0 NLRP3i Jan 2019
NLRP3 inflammasome inhibitor
6802 6 TMR Tre Feb 2019
Fluorescent trehalose; selectively labels mycobacterial cell envelope
6934 673 A Jun 2019
ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
6868 8-Azaadenosine May 2019
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
6493 A 317491 sodium salt May 2019
Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive
6313 A 33 May 2019
Potent and selective PDE4B inhibitor
6470 A 410099.1 Feb 2019
High affinity XIAP antagonist; active in vivo
6715 A 71915 Jan 2019
Highly potent and competitive NPRA antagonist
6759 AA 147 Feb 2019
ER proteostasis regulator
6960 ABT 199 Jul 2019
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
6770 ABT 639 Mar 2019
CaV3.2 and CaV3.1 channel blocker; orally bioavailable
6835 ABT 737 May 2019
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
6766 AC 1903 Mar 2019
Selective TRPC5 blocker
6840 AD 01 May 2019
FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic
6495 AM 12 May 2019
TRPC5 inhibitor
6874 AMG 333 Jul 2019
Potent and selective TRPM8 antagonist; active in vivo
5862 ARN 14686 Apr 2019
Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe
6763 AVE 1625 Apr 2019
Potent and selective CB1 receptor antagonist
6806 AZ 3451 Apr 2019
Potent negative allosteric modulator of PAR2
6812 Afatinib dimaleate Mar 2019
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
6861 Anle138b May 2019
Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
6818 Artemether Mar 2019
Antimalarial; also inhibits neuroinflammation
6827 Artesunate Mar 2019
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
6834 Auxin Mar 2019
Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone
6561 BAY 6035 Jun 2019
Potent and selective SMYD3 inhibitor
6817 BAY 8002 May 2019
Potent dual MCT1/2 inhibitor; orally bioavailable
6246 BF 738735 Apr 2019
Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
6518 BI 01383298 Feb 2019
Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor
6665 BI 9321 May 2019
Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
6872 BQCA May 2019
Positive allosteric modulator of M1 receptors
1304 BW-B 70C Mar 2019
5-Lipoxygenase inhibitor
6786 BzF Feb 2019
Photoreactive unnatural amino acid; photo-crosslinker
6724 CBA Feb 2019
Selective TRPM4 blocker
6695 CHIR 98014 Feb 2019
Highly potent and selective GSK-3 inhibitor
6753 CHS 828 Mar 2019
NAMPT inhibitor; active in vivo and cytotoxic
6948 CRBN-6-5-5-VHL Jun 2019
Potent and selective cereblon degrader; cell-permeable
6690 Ceralifimod May 2019
Highly potent and selective S1P1 and S1P5 agonist
6905 Ceritinib Jun 2019
Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
6702 Cerulenin Feb 2019
Irreversible fatty acid synthase inhibitor
6798 Click N-Acetylmuramic acid - alkyne Feb 2019
Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes
6830 Conivaptan hydrochloride Mar 2019
Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable
6434 DFHO Apr 2019
Mimic of RFP fluorophore for imaging RNA in living cells
6706 DPNB-ABT 594 Mar 2019
Caged ABT 594; suitable for one- or two-photon photolysis
6903 DPTIP Jul 2019
Potent and selective N-SMase2 inhibitor; brain penetrant
6755 Darapladib Mar 2019
Potent lp-PLA2 inhibitor
6793 Dasatinib Feb 2019
Highly potent pan-Src/Bcr-Abl inhibitor
6882 DiFMUP May 2019
Fluorescent phosphatase substrate
6705 Diminazene aceturate Feb 2019
ASIC blocker; antihyperalgesic
6785 E 7820 Apr 2019
α2 integrin inhibitor; anti-angiogenic
6698 ELA-11 (human) Jan 2019
High affinity apelin agonist
6697 ELA-21 (human) Jan 2019
High affinity apelin agonist
6832 Ec2la May 2019
Positive allosteric modulator of CB2 receptors; active in vivo
6717 FFN 270 May 2019
Fluorescent substrate for NET and VMAT2
6653 FM19G11 Feb 2019
HIF α-subunit inhibitor
6784 FTBMT Mar 2019
Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
6926 Fenoprofen calcium May 2019
Positive allosteric modulator of MC3 receptors; exhibits biased signaling
6490 GNE 2861 Mar 2019
Group II PAK inhibitor; potently inhibits PAK4 and PAK 6
6433 GSK 1016790A May 2019
Potent TRPV4 agonist; active in vivo
6790 GSK 126 Jul 2019
Very high affinity and selective EZH2 inhibitor
6362 GSK 143 May 2019
Syk inhibitor
6709 GSK 2018682 Jan 2019
S1P1 and S1P5 agonist
6837 GSK 923295A May 2019
Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor
6935 GSK J5 HCl May 2019
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
6956 Galunisertib Jun 2019
ALK4 and ALK5 (TGFβRI) inhibitor
6228 H10 Jul 2019
PARP14 inhibitor; cell-permeable
6521 I-BET 762 Jun 2019
Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable.
6813 Ibrutinib Apr 2019
Potent and selective BTK inhibitor
6782 Indisulam May 2019
Molecular glue; pre-mRNA splicing modulator
6553 JF-NP-26 Jan 2019
Caged Raseglurant (Cat. No. 4416)
6378 JMS 17-2 hydrochloride Apr 2019
CX3CR1 antagonist
6439 JNJ 0966 Mar 2019
Pro-MMP9 activation inhibitor
6500 Janelia Fluor® 549, Maleimide Jul 2019
Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group
6502 Janelia Fluor® 549, Tetrazine Apr 2019
Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry
6787 KI-7 Mar 2019
Positive allosteric modulator of A2B receptors
6272 KYP 2047 Mar 2019
High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant
5026 KYT 0353 May 2019
Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo
6664 Kinesore Mar 2019
Kinesin-1 modulator; cell permeable
6644 KuWal151 Jan 2019
Potent and selective CLK inhibitor
6809 L-DON Feb 2019
Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
6752 LDC 000067 Mar 2019
Potent and selective CDK9 inhibitor
6754 LJI308 Mar 2019
Potent pan-RSK inhibitor
6510 LNT 1 Apr 2019
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
5984 LY 2955303 Jan 2019
High affinity and selective RARγ antagonist
6854 LY 3009120 Jun 2019
Potent pan-Raf kinase inhibitor
6811 Lapatinib Apr 2019
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor
6668 ML 184 Jan 2019
Selective GPR55 agonist; also promotes NSC proliferation and differentiation
6429 ML 210 Mar 2019
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
6887 ML 335 Jun 2019
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
6856 α-Mangostin Apr 2019
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
6819 Mefloquine hydrochloride Mar 2019
Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal
6898 Mitochondrial fusion promoter M1 May 2019
Mitochondrial fusion promoter
6535 NVP 2 Feb 2019
Potent and selective ATP-competitive CDK9 inhibitor
6489 Ocean Blue, SE Jun 2019
Blue fluorescent dye; supplied as NHS ester
6792 Omipalisib May 2019
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
6771 PHPS1 sodium salt May 2019
Shp2 (PTPN11) inhibitor
6891 PND 1186 May 2019
Potent FAK inhibitor; orally bioavailable
6748 PRX 07034 Apr 2019
Potent and selective 5-HT6 antagonist
6885 PU 23 May 2019
Multidrug resistance protein (MRP) 4 inhibitor
6451 Pexacerfont Apr 2019
Potent and selective CRF1 antagonist; anxiolytic
6716 Pomalidomide - linker 4 Jun 2019
Pomalidomide-alkylC5-amine
6851 Pomalidomide - linker 7 Mar 2019
Pomalidomide-alkylC2-amine
6963 Pomalidomide - linker 8 Jun 2019
Pomalidomide-PEG4-ethylamine
6577 Pyridone 6 Feb 2019
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
6788 Quizartinib Jan 2019
Highly potent FLT3 inhibitor
6845 RCM 1 May 2019
FOXM1 inhibitor
6728 RGFP 966 Mar 2019
Potent and selective HDAC3 inhibitor
6567 RI-STAD 2 Feb 2019
AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
6760 Raphin 1 Mar 2019
Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant
6957 Reparixin L-lysine salt Jun 2019
Potent CXCR1 and CXCR2 allosteric antagonist
6867 Rhein Apr 2019
FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3
6778 S 38093 May 2019
Selective H3 antagonist and inverse agonist; antinociceptive
6708 SAH-EZH2 May 2019
EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
6881 SB 4 May 2019
Potent BMP4 agonist
6245 SM 16 Jan 2019
Potent TGF-βRI inhibitor; orally bioavailable
6597 SPRi 3 Feb 2019
Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells
6566 STAD 2 Feb 2019
AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
6815 Selumetinib May 2019
Potent and selective MEK inhibitor; orally bioavailable
6829 (R)-Shikonin May 2019
PTEN inhibitor; induces necroptosis; anti-inflammatory
6740 Siramesine hydrochloride Apr 2019
High affinity σ agonist (σ2 > σ1)
6816 Sitagliptin phosphate Feb 2019
Potent and selective DPP IV inhibitor
6814 Sorafenib Apr 2019
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
6575 StRIP16 Apr 2019
Rab8a GTPase-binding stapled peptide
6634 Surfen Apr 2019
Heparin sulfate antagonist
6726 T-peptide Jan 2019
Cytotoxic Tau peptide; cell permeable
6777 TAK 375 Jan 2019
Very high affinity and selective melatonin receptor agonist
6884 TC SL C5 Jul 2019
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
6621 TFAX 488, TFP Jan 2019
Green fluorescent dye; amine reactive
6749 TH 5487 Apr 2019
Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
6334 THDOC Jan 2019
Positive modulator of GABAA receptors; endogenous neurosteroid
6746 TL 13-110 Apr 2019
Negative control for TL 13-112
6745 TL 13-112 Apr 2019
Selective ALK Degrader
6744 TL 13-12 Apr 2019
Selective ALK degrader
6747 TL 13-22 Apr 2019
Negative control for TL 13-12
6908 TR 14035 Jul 2019
Potent integrin α4β7 and α4β1 antagonist; orally bioavailable
3719 Talabostat mesylate Feb 2019
Potent DPP IV inhibitor; activates NLRP1b inflammasome
6266 Taxol Janelia Fluor® 646 Feb 2019
Red fluorescent taxol derivative
6949 Thalidomide - linker 10 May 2019
Thalidomide-alkylC2-amine
6951 Thalidomide - linker 12 May 2019
Thalidomide-PEG5-ethylamine
6966 Thalidomide - linker 13 Jun 2019
Thalidomide-PEG1-ethylamine
6967 Thalidomide - linker 14 Jun 2019
Thalidomide-PEG2-ethylamine
6968 Thalidomide - linker 15 Jun 2019
Thalidomide-alkylC6-amine
6850 Thalidomide - linker 6 Mar 2019
Thalidomide-alkylC2-Amine
6917 Thalidomide - linker 9 Jun 2019
Thalidomide-alkylC4-amine
6864 Ticagrelor Apr 2019
High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1
6801 Tocriscreen Epigenetics Library Jul 2019
A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions)
6762 Urolithin A Apr 2019
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
6880 VH 032 - linker 10 Apr 2019
VH 032-alkylC10-amine
6890 VH 032 - linker 11 Apr 2019
VH 032-AlkylC8-Amine
6907 VH 032 - linker 12 Apr 2019
VH 032-PEG2-amine
6679 VH 032 - linker 4 Apr 2019
VH 032-PEG3-CH2CH2COOH
6852 VH 032 - linker 7 Apr 2019
VH 032-alkylC2-amine
6853 VH 032 - linker 8 Apr 2019
VH 032-alkylC6-amine
6879 VH 032 - linker 9 Apr 2019
VH 032-PEG1-amine
6909 VH 032 phenol - linker 1 Jul 2019
VH 032 phenol-alkylC4-amine
6910 VH 032 phenol - linker 2 Jul 2019
VH 032 phenol-alkylC6-amine
6877 VU 0134992 Jul 2019
Kir4.1 blocker
6355 VU 0650991 Apr 2019
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
6692 WM 1119 Mar 2019
High affinity KAT6A (MOZ) competitive inhibitor
6719 YH 239-EE Feb 2019
Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
6713 ZXH 3-26 Jun 2019
Potent and selective BRD4 degrader
6969 cis VH 032, amine dihydrochloride Jul 2019
Negative control for VH 032, amine (Cat. No. 6462)
6605 dTAG-13 Mar 2019
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation
6607 dTRIM 24 Jan 2019
TRIM24 degrading PROTAC
6659 sBADA Feb 2019
Green fluorescent D-amino acid for labeling peptidoglycans in bacteria
6865 uPSEM 792 hydrochloride Apr 2019
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
6866 uPSEM 817 tartrate Mar 2019
Highly potent and selective uPSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant