Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6774 | 16673-34-0 NLRP3i | Jan 2019 |
| NLRP3 inflammasome inhibitor | ||
| 6802 | 6 TMR Tre | Feb 2019 |
| Fluorescent trehalose; selectively labels mycobacterial cell envelope | ||
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
| 6868 | 8-Azaadenosine | May 2019 |
| ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | ||
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
| 6470 | A 410099.1 | Feb 2019 |
| High affinity XIAP antagonist; active in vivo | ||
| 6715 | A 71915 | Jan 2019 |
| Highly potent and competitive NPRA antagonist | ||
| 6759 | AA 147 | Feb 2019 |
| ER proteostasis regulator | ||
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
| 6770 | ABT 639 | Mar 2019 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | ||
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
| 6766 | AC 1903 | Mar 2019 |
| Selective TRPC5 blocker | ||
| 6840 | AD 01 | May 2019 |
| FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
| 5862 | ARN 14686 | Apr 2019 |
| Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 6763 | AVE 1625 | Apr 2019 |
| Potent and selective CB1 receptor antagonist | ||
| 6806 | AZ 3451 | Apr 2019 |
| Potent negative allosteric modulator of PAR2 | ||
| 6812 | Afatinib dimaleate | Mar 2019 |
| Potent dual specificity EGFR/HER2 inhibitor; active in vivo | ||
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
| 6818 | Artemether | Mar 2019 |
| Antimalarial; also inhibits neuroinflammation | ||
| 6827 | Artesunate | Mar 2019 |
| Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | ||
| 6834 | Auxin | Mar 2019 |
| Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone | ||
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
| 6246 | BF 738735 | Apr 2019 |
| Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor | ||
| 6518 | BI 01383298 | Feb 2019 |
| Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor | ||
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
| 1304 | BW-B 70C | Mar 2019 |
| 5-Lipoxygenase inhibitor | ||
| 6786 | BzF | Feb 2019 |
| Photoreactive unnatural amino acid; photo-crosslinker | ||
| 6724 | CBA | Feb 2019 |
| Selective TRPM4 blocker | ||
| 6695 | CHIR 98014 | Feb 2019 |
| Highly potent and selective GSK-3 inhibitor | ||
| 6753 | CHS 828 | Mar 2019 |
| NAMPT inhibitor; active in vivo and cytotoxic | ||
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
| 6702 | Cerulenin | Feb 2019 |
| Irreversible fatty acid synthase inhibitor | ||
| 6798 | Click N-Acetylmuramic acid - alkyne | Feb 2019 |
| Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes | ||
| 6830 | Conivaptan hydrochloride | Mar 2019 |
| Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | ||
| 6434 | DFHO | Apr 2019 |
| Mimic of RFP fluorophore for imaging RNA in living cells | ||
| 6706 | DPNB-ABT 594 | Mar 2019 |
| Caged ABT 594; suitable for one- or two-photon photolysis | ||
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 6755 | Darapladib | Mar 2019 |
| Potent lp-PLA2 inhibitor | ||
| 6793 | Dasatinib | Feb 2019 |
| Highly potent pan-Src/Bcr-Abl inhibitor | ||
| 6882 | DiFMUP | May 2019 |
| Fluorescent phosphatase substrate | ||
| 6705 | Diminazene aceturate | Feb 2019 |
| ASIC blocker; antihyperalgesic | ||
| 6785 | E 7820 | Apr 2019 |
| α2 integrin inhibitor; anti-angiogenic | ||
| 6698 | ELA-11 (human) | Jan 2019 |
| High affinity apelin agonist | ||
| 6697 | ELA-21 (human) | Jan 2019 |
| High affinity apelin agonist | ||
| 6832 | Ec2la | May 2019 |
| Positive allosteric modulator of CB2 receptors; active in vivo | ||
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
| 6653 | FM19G11 | Feb 2019 |
| HIF α-subunit inhibitor | ||
| 6784 | FTBMT | Mar 2019 |
| Potent and selective GPR52 agonist; orally bioavailable and BBB permeable | ||
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
| 6490 | GNE 2861 | Mar 2019 |
| Group II PAK inhibitor; potently inhibits PAK4 and PAK 6 | ||
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
| 6362 | GSK 143 | May 2019 |
| Syk inhibitor | ||
| 6709 | GSK 2018682 | Jan 2019 |
| S1P1 and S1P5 agonist | ||
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
| 6813 | Ibrutinib | Apr 2019 |
| Potent and selective BTK inhibitor | ||
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
| 6553 | JF-NP-26 | Jan 2019 |
| Caged Raseglurant (Cat. No. 4416) | ||
| 6378 | JMS 17-2 hydrochloride | Apr 2019 |
| CX3CR1 antagonist | ||
| 6439 | JNJ 0966 | Mar 2019 |
| Pro-MMP9 activation inhibitor | ||
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
| 6502 | Janelia Fluor® 549, Tetrazine | Apr 2019 |
| Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry | ||
| 6787 | KI-7 | Mar 2019 |
| Positive allosteric modulator of A2B receptors | ||
| 6272 | KYP 2047 | Mar 2019 |
| High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant | ||
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
| 6664 | Kinesore | Mar 2019 |
| Kinesin-1 modulator; cell permeable | ||
| 6644 | KuWal151 | Jan 2019 |
| Potent and selective CLK inhibitor | ||
| 6809 | L-DON | Feb 2019 |
| Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters | ||
| 6752 | LDC 000067 | Mar 2019 |
| Potent and selective CDK9 inhibitor | ||
| 6754 | LJI308 | Mar 2019 |
| Potent pan-RSK inhibitor | ||
| 6510 | LNT 1 | Apr 2019 |
| Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response | ||
| 5984 | LY 2955303 | Jan 2019 |
| High affinity and selective RARγ antagonist | ||
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
| 6811 | Lapatinib | Apr 2019 |
| Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | ||
| 6668 | ML 184 | Jan 2019 |
| Selective GPR55 agonist; also promotes NSC proliferation and differentiation | ||
| 6429 | ML 210 | Mar 2019 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | ||
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
| 6856 | α-Mangostin | Apr 2019 |
| Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | ||
| 6819 | Mefloquine hydrochloride | Mar 2019 |
| Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | ||
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
| 6535 | NVP 2 | Feb 2019 |
| Potent and selective ATP-competitive CDK9 inhibitor | ||
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
| 6771 | PHPS1 sodium salt | May 2019 |
| Shp2 (PTPN11) inhibitor | ||
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
| 6748 | PRX 07034 | Apr 2019 |
| Potent and selective 5-HT6 antagonist | ||
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
| 6451 | Pexacerfont | Apr 2019 |
| Potent and selective CRF1 antagonist; anxiolytic | ||
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
| 6851 | Pomalidomide - linker 7 | Mar 2019 |
| Pomalidomide-alkylC2-amine | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6577 | Pyridone 6 | Feb 2019 |
| Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable | ||
| 6788 | Quizartinib | Jan 2019 |
| Highly potent FLT3 inhibitor | ||
| 6845 | RCM 1 | May 2019 |
| FOXM1 inhibitor | ||
| 6728 | RGFP 966 | Mar 2019 |
| Potent and selective HDAC3 inhibitor | ||
| 6567 | RI-STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable | ||
| 6760 | Raphin 1 | Mar 2019 |
| Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant | ||
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
| 6867 | Rhein | Apr 2019 |
| FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | ||
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; antinociceptive | ||
| 6708 | SAH-EZH2 | May 2019 |
| EZH2/EDD interaction inhibitor; suppresses PCR2 complex function | ||
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
| 6245 | SM 16 | Jan 2019 |
| Potent TGF-βRI inhibitor; orally bioavailable | ||
| 6597 | SPRi 3 | Feb 2019 |
| Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells | ||
| 6566 | STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable | ||
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
| 6829 | (R)-Shikonin | May 2019 |
| PTEN inhibitor; induces necroptosis; anti-inflammatory | ||
| 6740 | Siramesine hydrochloride | Apr 2019 |
| High affinity σ agonist (σ2 > σ1) | ||
| 6816 | Sitagliptin phosphate | Feb 2019 |
| Potent and selective DPP IV inhibitor | ||
| 6814 | Sorafenib | Apr 2019 |
| Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | ||
| 6575 | StRIP16 | Apr 2019 |
| Rab8a GTPase-binding stapled peptide | ||
| 6634 | Surfen | Apr 2019 |
| Heparin sulfate antagonist | ||
| 6726 | T-peptide | Jan 2019 |
| Cytotoxic Tau peptide; cell permeable | ||
| 6777 | TAK 375 | Jan 2019 |
| Very high affinity and selective melatonin receptor agonist | ||
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
| 6621 | TFAX 488, TFP | Jan 2019 |
| Green fluorescent dye; amine reactive | ||
| 6749 | TH 5487 | Apr 2019 |
| Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
| 6334 | THDOC | Jan 2019 |
| Positive modulator of GABAA receptors; endogenous neurosteroid | ||
| 6746 | TL 13-110 | Apr 2019 |
| Negative control for TL 13-112 | ||
| 6745 | TL 13-112 | Apr 2019 |
| Selective ALK Degrader | ||
| 6744 | TL 13-12 | Apr 2019 |
| Selective ALK degrader | ||
| 6747 | TL 13-22 | Apr 2019 |
| Negative control for TL 13-12 | ||
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 antagonist; orally bioavailable | ||
| 3719 | Talabostat mesylate | Feb 2019 |
| Potent DPP IV inhibitor; activates NLRP1b inflammasome | ||
| 6266 | Taxol Janelia Fluor® 646 | Feb 2019 |
| Red fluorescent taxol derivative | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6850 | Thalidomide - linker 6 | Mar 2019 |
| Thalidomide-alkylC2-Amine | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
| 6864 | Ticagrelor | Apr 2019 |
| High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1 | ||
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
| 6762 | Urolithin A | Apr 2019 |
| PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro | ||
| 6880 | VH 032 - linker 10 | Apr 2019 |
| VH 032-alkylC10-amine | ||
| 6890 | VH 032 - linker 11 | Apr 2019 |
| VH 032-AlkylC8-Amine | ||
| 6907 | VH 032 - linker 12 | Apr 2019 |
| VH 032-PEG2-amine | ||
| 6679 | VH 032 - linker 4 | Apr 2019 |
| VH 032-PEG3-CH2CH2COOH | ||
| 6852 | VH 032 - linker 7 | Apr 2019 |
| VH 032-alkylC2-amine | ||
| 6853 | VH 032 - linker 8 | Apr 2019 |
| VH 032-alkylC6-amine | ||
| 6879 | VH 032 - linker 9 | Apr 2019 |
| VH 032-PEG1-amine | ||
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
| 6355 | VU 0650991 | Apr 2019 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | ||
| 6692 | WM 1119 | Mar 2019 |
| High affinity KAT6A (MOZ) competitive inhibitor | ||
| 6719 | YH 239-EE | Feb 2019 |
| Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity | ||
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
| 6605 | dTAG-13 | Mar 2019 |
| Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation | ||
| 6607 | dTRIM 24 | Jan 2019 |
| TRIM24 degrading PROTAC | ||
| 6659 | sBADA | Feb 2019 |
| Green fluorescent D-amino acid for labeling peptidoglycans in bacteria | ||
| 6865 | uPSEM 792 hydrochloride | Apr 2019 |
| Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6866 | uPSEM 817 tartrate | Mar 2019 |
| Highly potent and selective uPSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant |