Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 6701 | 1A-116 | Jul 2019 |
| Rac1 inhibitor; blocks Rac1-P-Rex1 interaction | ||
| 7005 | 4-Thiouridine | Sep 2019 |
| Photoreactive uridine analog for RNA sequencing | ||
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
| 6972 | A 1899 | Sep 2019 |
| Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker | ||
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
| 6481 | AP 14145 hydrochloride | Nov 2019 |
| KCa2 channel negative allosteric modulator | ||
| 5861 | ARN 726 | Aug 2019 |
| Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 4265 | AS 1842856 | Nov 2019 |
| Potent and selective Foxo1 inhibitor; orally bioavailable | ||
| 6870 | AZ 12799734 | Nov 2019 |
| Potent TGF-βRI inhibitor | ||
| 6978 | AZD 5363 | Aug 2019 |
| Potent pan-AKT inhibitor | ||
| 6930 | Amphotericin B | Aug 2019 |
| Forms monovalent ion channels in lipid bilyers; antifungal | ||
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
| 6764 | B 973B | Sep 2019 |
| Positive allosteric modulator of α7 nAChRs; analgesic | ||
| 6857 | BAY 293 | Sep 2019 |
| Potent KRas/SOS1 interaction inhibitor | ||
| 6906 | BAY 293 Negative Control | Sep 2019 |
| Negative control for BAY 293 (Cat. No. 6857) | ||
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
| 6980 | BAY 87-2243 | Sep 2019 |
| Mitochondrial complex I inhibitor | ||
| 6703 | BGP 15 | Jul 2019 |
| PARP inhibitor; cytoprotectant | ||
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
| 6974 | BMS 986094 | Oct 2019 |
| Prodrug of HCV RNA polymerase inhibitor 2'-C-methyl guanosine triphosphate; potent HCV replication inhibitor | ||
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
| 6921 | BSJ-03-123 | Aug 2019 |
| Selective Cdk6 degrader | ||
| 6938 | BSJ-03-204 | Aug 2019 |
| Selective Cdk4/6 degrader | ||
| 6937 | BSJ-04-132 | Sep 2019 |
| Selective Cdk4 degrader | ||
| 6922 | BSJ-Bump | Aug 2019 |
| Negative control for BSJ-03-123 (Cat. No. 6921) | ||
| 6940 | BTD | Oct 2019 |
| Selective TRPC5 activator | ||
| 6573 | Biotin-NAD+ | Oct 2019 |
| Biotinylated-NAD+; substrate for ADP-ribosylation | ||
| 6933 | CM 10 | Jul 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells | ||
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
| 6823 | CycLuc 1 | Jul 2019 |
| Synthetic luciferase substrate; brain penetrant; displays NIR emission | ||
| 6982 | Cyclosporin H | Oct 2019 |
| Viral transduction enhancer | ||
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 6986 | EG 00229 trifluoroacetate | Jul 2019 |
| Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 | ||
| 6859 | FITM | Aug 2019 |
| Potent and selective negative allosteric modulator of mGlu1 receptors | ||
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
| 6574 | Fluorescein-NAD+ | Oct 2019 |
| Fluorescent NAD+; substrate for ADP-ribosylation for use in PARP assays | ||
| 6776 | G5 | Jul 2019 |
| Ubiquitin isopeptidase inhibitor; induces apoptosis | ||
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
| 6927 | Glucagon (Human, Porcine) | Aug 2019 |
| Endogenous glucagon receptor agonist | ||
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
| 6994 | HODHBt | Aug 2019 |
| STAT5-SUMO protein-protein interaction inhibitor | ||
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
| 6904 | Idasanutlin | Jul 2019 |
| Potent MDM2 inhibitor; inhibits MDM2-p53 interaction | ||
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
| 6201 | J 2156 | Aug 2019 |
| Selective high affinity human sst4 agonist | ||
| 6765 | JTP 103237 | Aug 2019 |
| Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor | ||
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
| 6797 | KLD 12 | Sep 2019 |
| Self-assembling peptide; forms hydrogel to support cell growth | ||
| 7065 | Kainic acid (synthetic) | Oct 2019 |
| Kainate agonist; excitant and neurotoxin | ||
| 6751 | (R)-(-)-Ketamine hydrochloride | Jul 2019 |
| NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine | ||
| 6954 | L-Buthionine sulfoximine | Jul 2019 |
| Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis | ||
| 7020 | LDV | Sep 2019 |
| α4β1 (VLA-4) ligand | ||
| 6691 | LP 922056 | Oct 2019 |
| Notum inhibitor; activates Wnt signaling | ||
| 7027 | LY 2033298 | Sep 2019 |
| Selective positive allosteric modulator of M4 receptors; active in vivo; antipsychotic | ||
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
| 7045 | (±)-α-Lipoamide | Oct 2019 |
| Phase-separated condensate modifier; orally bioavailable | ||
| 7044 | (±)-α-Lipoic acid | Nov 2019 |
| Liquid-liquid phase separated condensate modifier; reduces stress granule formation | ||
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
| 6888 | ML 402 | Sep 2019 |
| Selective TREK channel activator | ||
| 6889 | ML 418 | Sep 2019 |
| Kir 7.1 inhibitor; also inhibits Kir 6.2 | ||
| 6886 | ML 67-33 | Jul 2019 |
| K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | ||
| 6803 | MRK 740 | Sep 2019 |
| Potent PRDM9 inhibitor | ||
| 6109 | Methylnaltrexone bromide | Aug 2019 |
| μ antagonist; peripherally restricted | ||
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
| 6863 | N6-Cyclohexyladenosine | Nov 2019 |
| High affinity A1 receptor agonist | ||
| 6902 | OLT 1177 | Jul 2019 |
| NLRP3 inflammasome inhibitor; disrupts inflammasome formation | ||
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
| 7013 | OptoBI-1 | Nov 2019 |
| Photoswitchable TRPC3/6/7 agonist | ||
| 6924 | Oridonin | Jul 2019 |
| High affinity NLRP3 inflammasome inhibitor | ||
| 6897 | P110 | Oct 2019 |
| Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable | ||
| 7006 | PDD 00017272 | Sep 2019 |
| Potent PARG inhibitor | ||
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6054 | R162 | Aug 2019 |
| Glutamate dehydrogenase (GDH1) inhibitor | ||
| 7066 | RCGD 423 | Nov 2019 |
| gp130 modulator; activates JAK/STAT signaling | ||
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive | ||
| 6920 | SAH-SOS1A | Jul 2019 |
| KRas/SOS1 interaction inhibitor | ||
| 6847 | TAT-GluA2 3Y | Oct 2019 |
| Inhibitor of AMPA receptor endocytosis | ||
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
| 6619 | TFAX 488, SE | Aug 2019 |
| Green fluorescent dye; amine reactive | ||
| 6623 | TFAX 546, SE | Aug 2019 |
| Yellow fluorescent dye; amine reactive | ||
| 6899 | TH 257 | Sep 2019 |
| Potent and selective allosteric LIMK 1/2 inhibitor | ||
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable | ||
| 6427 | Tafluprost | Sep 2019 |
| Very high affinity FP receptor agonist | ||
| 6950 | Thalidomide - linker 11 | Sep 2019 |
| Thalidomide-PEG3-ethylamine | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
| 6895 | VU 0424465 | Oct 2019 |
| Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity | ||
| 6932 | VU 0467485 | Oct 2019 |
| Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant | ||
| 6893 | VU 6005649 | Sep 2019 |
| Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | ||
| 6936 | VZ 185 | Oct 2019 |
| Potent and selective BRD7/9 Degrader | ||
| 6821 | ZAP 180013 | Sep 2019 |
| Zap70 inhibitor; inhibits interaction with ITAMs | ||
| 5847 | ZLD 1039 | Sep 2019 |
| Potent and selective EZH2 inhibitor; orally bioavailable | ||
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6970 | aTAG 2139 | Sep 2019 |
| Degrader of MTH1 fusion proteins for use within the aTAG system | ||
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
| 7046 | 1,6-Hexanediol | Sep 2019 |
| Tool for probing liquid-liquid phase separation | ||
| 6757 | t-TUCB | Jul 2019 |
| Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive |