New Products

View all New Products Alphabetically

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

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Cat. No. Product Name / Activity Date Added
6701 1A-116 Jul 2019
Rac1 inhibitor; blocks Rac1-P-Rex1 interaction
7005 4-Thiouridine Sep 2019
Photoreactive uridine analog for RNA sequencing
6934 673 A Jun 2019
ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
6868 8-Azaadenosine May 2019
ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal
6972 A 1899 Sep 2019
Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
6493 A 317491 sodium salt May 2019
Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive
6313 A 33 May 2019
Potent and selective PDE4B inhibitor
6960 ABT 199 Jul 2019
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
6770 ABT 639 Mar 2019
CaV3.2 and CaV3.1 channel blocker; orally bioavailable
6835 ABT 737 May 2019
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
6766 AC 1903 Mar 2019
Selective TRPC5 blocker
6840 AD 01 May 2019
FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic
6495 AM 12 May 2019
TRPC5 inhibitor
6874 AMG 333 Jul 2019
Potent and selective TRPM8 antagonist; active in vivo
5862 ARN 14686 Apr 2019
Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe
5861 ARN 726 Aug 2019
Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe
6763 AVE 1625 Apr 2019
Potent and selective CB1 receptor antagonist
6806 AZ 3451 Apr 2019
Potent negative allosteric modulator of PAR2 receptors
6978 AZD 5363 Aug 2019
Potent pan-AKT inhibitor
6930 Amphotericin B Aug 2019
Forms monovalent ion channels in lipid bilyers; antifungal
6861 Anle138b May 2019
Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
6818 Artemether Mar 2019
Antimalarial; also inhibits neuroinflammation
6764 B 973B Sep 2019
Positive allosteric modulator of α7 nAChRs; analgesic
6857 BAY 293 Sep 2019
Potent KRas/SOS1 interaction inhibitor
6906 BAY 293 Negative Control Sep 2019
Negative control for BAY 293 (Cat. No. 6857)
6561 BAY 6035 Jun 2019
Potent and selective SMYD3 inhibitor
6817 BAY 8002 May 2019
Potent dual MCT1/2 inhibitor; orally bioavailable
6980 BAY 87-2243 Sep 2019
Mitochondrial complex I inhibitor
6246 BF 738735 Apr 2019
Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
6703 BGP 15 Jul 2019
PARP inhibitor; cytoprotectant
6665 BI 9321 May 2019
Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
6872 BQCA May 2019
Positive allosteric modulator of M1 receptors
6921 BSJ-03-123 Aug 2019
Selective Cdk6 degrader
6938 BSJ-03-204 Aug 2019
Selective Cdk4/6 degrader
6937 BSJ-04-132 Sep 2019
Selective Cdk4 degrader
6922 BSJ-Bump Aug 2019
Negative control for BSJ-03-123
6753 CHS 828 Mar 2019
NAMPT inhibitor; active in vivo and cytotoxic
6933 CM 10 Jul 2019
ALDH1A inhibitor; depletes CD133+ cancer stem cells
6948 CRBN-6-5-5-VHL Jun 2019
Potent and selective cereblon degrader; cell-permeable
6690 Ceralifimod May 2019
Highly potent and selective S1P1 and S1P5 agonist
6905 Ceritinib Jun 2019
Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
6823 CycLuc 1 Jul 2019
Synthetic luciferase substrate; brain penetrant; displays NIR emission
6434 DFHO Apr 2019
Mimic of RFP fluorophore for imaging RNA in living cells
6903 DPTIP Jul 2019
Potent and selective N-SMase2 inhibitor; brain penetrant
6882 DiFMUP May 2019
Fluorescent phosphatase substrate
6785 E 7820 Apr 2019
α2 integrin inhibitor; anti-angiogenic
6986 EG 00229 trifluoroacetate Jul 2019
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
6832 Ec2la May 2019
Positive allosteric modulator of CB2 receptors; active in vivo
6717 FFN 270 May 2019
Fluorescent substrate for NET and VMAT2
6859 FITM Aug 2019
Potent and selective negative allosteric modulator of mGlu1 receptors
6784 FTBMT Mar 2019
Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
6926 Fenoprofen calcium May 2019
Positive allosteric modulator of MC3 receptors; exhibits biased signaling
6776 G5 Jul 2019
Ubiquitin isopeptidase inhibitor; induces apoptosis
6433 GSK 1016790A May 2019
Potent TRPV4 agonist; active in vivo
6790 GSK 126 Jul 2019
Very high affinity and selective EZH2 inhibitor
6362 GSK 143 May 2019
Syk inhibitor
6837 GSK 923295A May 2019
Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor
6935 GSK J5 HCl May 2019
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
6956 Galunisertib Jun 2019
ALK4 and ALK5 (TGFβRI) inhibitor
6927 Glucagon (Human, Porcine) Aug 2019
Endogenous glucagon receptor agonist
6228 H10 Jul 2019
PARP14 inhibitor; cell-permeable
6994 HODHBt Aug 2019
STAT5-SUMO protein-protein interaction inhibitor
6521 I-BET 762 Jun 2019
Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable.
6813 Ibrutinib Apr 2019
Potent and selective BTK inhibitor
6904 Idasanutlin Jul 2019
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
6782 Indisulam May 2019
Molecular glue; pre-mRNA splicing modulator
6201 J 2156 Aug 2019
Selective high affinity human sst4 agonist
6378 JMS 17-2 hydrochloride Apr 2019
CX3CR1 antagonist
6765 JTP 103237 Aug 2019
Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor
6500 Janelia Fluor® 549, Maleimide Jul 2019
Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group
6502 Janelia Fluor® 549, Tetrazine Apr 2019
Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry
6787 KI-7 Mar 2019
Positive allosteric modulator of A2B receptors
6797 KLD 12 Sep 2019
Self-assembling peptide; forms hydrogel to support cell growth
5026 KYT 0353 May 2019
Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo
6751 (R)-(-)-Ketamine hydrochloride Jul 2019
NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine
6954 L-Buthionine sulfoximine Jul 2019
Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
6752 LDC 000067 Mar 2019
Potent and selective CDK9 inhibitor
7020 LDV Sep 2019
α4β1 (VLA-4) ligand
6510 LNT 1 Apr 2019
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
6854 LY 3009120 Jun 2019
Potent pan-Raf kinase inhibitor
6811 Lapatinib Apr 2019
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor
6887 ML 335 Jun 2019
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
6888 ML 402 Sep 2019
Selective TREK channel activator
6889 ML 418 Sep 2019
Kir 7.1 inhibitor; also inhibits Kir 6.2
6886 ML 67-33 Jul 2019
K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
6803 MRK 740 Sep 2019
Potent PRDM9 inhibitor
6856 α-Mangostin Apr 2019
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
6109 Methylnaltrexone bromide Aug 2019
μ antagonist; peripherally restricted
6898 Mitochondrial fusion promoter M1 May 2019
Mitochondrial fusion promoter
6902 OLT 1177 Jul 2019
NLRP3 inflammasome inhibitor; disrupts inflammasome formation
6489 Ocean Blue, SE Jun 2019
Blue fluorescent dye; supplied as NHS ester
6792 Omipalisib May 2019
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
6924 Oridonin Jul 2019
High affinity NLRP3 inflammasome inhibitor
6771 PHPS1 sodium salt May 2019
Shp2 (PTPN11) inhibitor
6891 PND 1186 May 2019
Potent FAK inhibitor; orally bioavailable
6748 PRX 07034 Apr 2019
Potent and selective 5-HT6 antagonist
6885 PU 23 May 2019
Multidrug resistance protein (MRP) 4 inhibitor
6451 Pexacerfont Apr 2019
Potent and selective CRF1 antagonist; anxiolytic
6716 Pomalidomide - linker 4 Jun 2019
Pomalidomide-alkylC5-amine
6963 Pomalidomide - linker 8 Jun 2019
Pomalidomide-PEG4-ethylamine
6054 R162 Aug 2019
Glutamate dehydrogenase (GDH1) inhibitor
6845 RCM 1 May 2019
FOXM1 inhibitor
6728 RGFP 966 Mar 2019
Potent and selective HDAC3 inhibitor
6957 Reparixin L-lysine salt Jun 2019
Potent CXCR1 and CXCR2 allosteric antagonist
6867 Rhein Apr 2019
FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3
6778 S 38093 May 2019
Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive
6708 SAH-EZH2 May 2019
EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
6920 SAH-SOS1A Jul 2019
KRas/SOS1 interaction inhibitor
6881 SB 4 May 2019
Potent BMP4 agonist
6815 Selumetinib May 2019
Potent and selective MEK inhibitor; orally bioavailable
6829 (R)-Shikonin May 2019
PTEN inhibitor; induces necroptosis; anti-inflammatory
6740 Siramesine hydrochloride Apr 2019
High affinity σ agonist (σ2 > σ1)
6814 Sorafenib Apr 2019
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
6575 StRIP16 Apr 2019
Rab8a GTPase-binding stapled peptide
6634 Surfen Apr 2019
Heparin sulfate antagonist
6884 TC SL C5 Jul 2019
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
6619 TFAX 488, SE Aug 2019
Green fluorescent dye; amine reactive
6623 TFAX 546, SE Aug 2019
Yellow fluorescent dye; amine reactive
6899 TH 257 Sep 2019
Potent and selective allosteric LIMK 1/2 inhibitor
6749 TH 5487 Apr 2019
Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
6746 TL 13-110 Apr 2019
Negative control for TL 13-112
6745 TL 13-112 Apr 2019
Selective ALK Degrader
6744 TL 13-12 Apr 2019
Selective ALK degrader
6747 TL 13-22 Apr 2019
Negative control for TL 13-12
6908 TR 14035 Jul 2019
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
6949 Thalidomide - linker 10 May 2019
Thalidomide-alkylC2-amine
6950 Thalidomide - linker 11 Sep 2019
Thalidomide-PEG3-ethylamine
6951 Thalidomide - linker 12 May 2019
Thalidomide-PEG5-ethylamine
6966 Thalidomide - linker 13 Jun 2019
Thalidomide-PEG1-ethylamine
6967 Thalidomide - linker 14 Jun 2019
Thalidomide-PEG2-ethylamine
6968 Thalidomide - linker 15 Jun 2019
Thalidomide-alkylC6-amine
6917 Thalidomide - linker 9 Jun 2019
Thalidomide-alkylC4-amine
6864 Ticagrelor Apr 2019
High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1
6801 Tocriscreen Epigenetics Library Jul 2019
A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions)
6762 Urolithin A Apr 2019
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
6880 VH 032 - linker 10 Apr 2019
VH 032-alkylC10-amine
6890 VH 032 - linker 11 Apr 2019
VH 032-AlkylC8-Amine
6907 VH 032 - linker 12 Apr 2019
VH 032-PEG2-amine
6679 VH 032 - linker 4 Apr 2019
VH 032-PEG3-CH2CH2COOH
6852 VH 032 - linker 7 Apr 2019
VH 032-alkylC2-amine
6853 VH 032 - linker 8 Apr 2019
VH 032-alkylC6-amine
6879 VH 032 - linker 9 Apr 2019
VH 032-PEG1-amine
6909 VH 032 phenol - linker 1 Jul 2019
VH 032 phenol-alkylC4-amine
6910 VH 032 phenol - linker 2 Jul 2019
VH 032 phenol-alkylC6-amine
6877 VU 0134992 Jul 2019
Kir4.1 blocker
6355 VU 0650991 Apr 2019
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
6893 VU 6005649 Sep 2019
Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant
6821 ZAP 180013 Sep 2019
Zap70 inhibitor; inhibits interaction with ITAMs
5847 ZLD 1039 Sep 2019
Potent and selective EZH2 inhibitor; orally bioavailable
6713 ZXH 3-26 Jun 2019
Potent and selective BRD4 degrader
6970 aTAG 2139 Sep 2019
Degrader of MTH1 fusion proteins for use within the aTAG system
6969 cis VH 032, amine dihydrochloride Jul 2019
Negative control for VH 032, amine (Cat. No. 6462)
6757 t-TUCB Jul 2019
Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive.
6865 uPSEM 792 hydrochloride Apr 2019
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
6866 uPSEM 817 tartrate Mar 2019
Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant