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Description: Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
Purity: ≥95% (HPLC)
Biological Activity for Angiopep-2-Cys
Angiopep-2-Cys is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present on brain endothelial cells and neurons. Angiopep-2-Cys is a conjugate of Angiopep-2 (Cat. No. 8828) and Cystein, and can be used to functionalize LNPs via thiol-maleimide click chemistry to target LRP1 receptors present on blood-brain barrier (BBB). mRNA LNPs functionalized with Angiopep-2-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.
Technical Data for Angiopep-2-Cys
| M. Wt | 2404.64 |
| Formula | C107H154N30O32S |
| Sequence | TFFYGGSRGKRNNFKTEEYC |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 906480-09-9 |
| PubChem ID | 170836226 |
| InChI Key | NTEVJSCQHIRPSH-ZYRNEBAYSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Angiopep-2-Cys
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Angiopep-2-Cys
Certificate of Analysis is currently unavailable on-line.
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References for Angiopep-2-Cys
References are publications that support the biological activity of the product.
Han et al (2025) Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett. 25 800 PMID: 39688915
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Citations for Angiopep-2-Cys
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