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Submit ReviewCys-T7 Peptide New
Description: Targeting peptide for the transferrin receptor (N-term Cys)
Purity: ≥95% (HPLC)
Biological Activity for Cys-T7 Peptide
Cys-T7 Peptide is a targeting peptide for the transferrin receptor (N-term Cys), a protein abundantly expressed on endothelial cells, including those forming the blood-brain barrier (BBB). Cys-T7 Peptide facilitates receptor-mediated endocytosis and transcytosis, making it an ideal targeting agent for drug delivery systems, such as lipid nanoparticles (LNPs), across biological barriers. N-term cys residue enables thiol-maleimide-based conjugation to DSPE-PEG 2000 Maleimide (Cat. No. 7947) commonly used to synthesize LNPs.
Technical Data for Cys-T7 Peptide
| M. Wt | 996.15 |
| Formula | C44H65N15O10S |
| Sequence | CHAIYPRH |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | SMAWGRDHSYDHOY-WBLMYSKVSA-N |
| Smiles | O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CC=C(C=C2)O)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CNC=N4)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cys-T7 Peptide
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Cys-T7 Peptide
References for Cys-T7 Peptide
References are publications that support the biological activity of the product.
Han et al (2011) Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer. Biomaterials 32 1242 PMID: 20971503
Han et al (2025) Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett. 25 800 PMID: 39688915
If you know of a relevant reference for Cys-T7 Peptide, please let us know.
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Keywords: Cys-T7 Peptide, Cys-T7 Peptide supplier, Lipid, nanoparticles, LNP, mRNA, peptides, brain, delivery, blood-brain, barrier, neurons, endocytosis, transcytosis, Nanoparticles, Biochemicals, and, Molecular, Biology, Endocytosis, 8904, Tocris Bioscience
Citations for Cys-T7 Peptide
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