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Description: Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
Purity: ≥95% (HPLC)
Biological Activity for Angiopep-2
Angiopep-2 is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present both on blood-brain barrier (BBB) and tumor cell membranes. Angiopep-2 binding to LRP1 facilitates receptor-mediated transcytosis of cargo across the BBB. Transcytosis-inducing molecular degraders of extracellular proteins (TransMoDEs), containing Angiopep-2 and modified to include a small-molecule ligand, induce target internalization that can cross the BBB in a variety of cell types.
Technical Data for Angiopep-2
| M. Wt | 2301.5 |
| Formula | C104H149N29O31 |
| Sequence | TFFYGGSRGKRNNFKTEEY |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| PubChem ID | 134687501 |
| InChI Key | RCVVJXYDPKEONQ-JVFWYHQTSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Angiopep-2
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Angiopep-2
References for Angiopep-2
References are publications that support the biological activity of the product.
Howell et al (2024) Bifunctional molecules that induce both targeted degradation and transcytosis of extracellular proteins in brain cells. J.Am.Chem.Soc. 146 16404 PMID: 38855935
Costagliola di Polidoro et al (2022) Revealing angiopep-2/LRP1 molecular interaction for optimal delivery to glioblastoma (GBM). Molecules 27 6696 PMID: 36235232
If you know of a relevant reference for Angiopep-2, please let us know.
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