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Description: Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines
Purity: ≥95% (HPLC)
Biological Activity for TransMoDE 3 Biotin
TransMoDE 3 Biotin is a biotinylated peptide capable of inducing both the degradation of target protein via lysosomal proteolysis and their bidirectional transcytosis of streptavidin across the blood-brain barrier. TransMoDE 3 Biotin is derived from the peptide Angiopep-2 (Cat. No. 8828).
Technical Data for TransMoDE 3 Biotin
| M. Wt | 2611.88 |
| Formula | C118H167N31O35S |
| Sequence |
TFFYGGSRGKRNNFKTEEY (Modifications: Thr-1 = N-terminal Ac, Lys-10 = N(ε)-Ac-Lys, Lys-15 = N(ε)-Biotin-Lys |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | SDTCWCCIHKRCLZ-MKHRACNQSA-N |
| Smiles | O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCNC(C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCNC(CCCC[C@@H]5SC[C@@](N6)([H])[C@]5([H])NC6=O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TransMoDE 3 Biotin
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for TransMoDE 3 Biotin
References for TransMoDE 3 Biotin
References are publications that support the biological activity of the product.
Howell et al (2024) Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells. J Am Chem Soc 146 16404 PMID: 38855935
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