BAY 9835

Pricing Availability   Qty
Description: Potent ADAMTS7 and ADAMTS12 inhibitor
Chemical Name: 5,6-Difluoro-N-[[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxo-4-imidazolidinyl]methyl]-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for BAY 9835

BAY 9835 is a potent ADAMTS7 and ADAMTS12 inhibitor (IC50 values are 6 nM and 30 nM, respectively). BAY 9835 is selective over other metalloproteases (ADAMTS4, ADAMTS5, ADAM8, ADAM10, ADAM17, MMP2, MMP12, MMP14, MMP15). BAY 9835 is the first orally bioavailable ADAMTS7 inhibitor.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 9835 probe summary on the SGC website.

Technical Data for BAY 9835

M. Wt 493.39
Formula C22H16F5N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3032487-31-0
PubChem ID 170836223
InChI Key LPQXZOJIUVOCAL-NRFANRHFSA-N
Smiles O=C(C1=C(C2=CC=C(C=C2)C(F)(F)F)C(F)=C(C=C1)F)NC[C@@]3(C4=CC=NN4C)NC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 9835

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.34 100

Preparing Stock Solutions for BAY 9835

The following data is based on the product molecular weight 493.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.13 mL 20.27 mL
5 mM 0.41 mL 2.03 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for BAY 9835

References are publications that support the biological activity of the product.

Meibom et al (2024) BAY-9835: Discovery of the first orally bioavailable ADAMTS7 inhibitor. J.Med.Chem. 67 2907 PMID: 38348661


If you know of a relevant reference for BAY 9835, please let us know.

View Related Products by Product Action

View all ADAM Inhibitors

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Citations for BAY 9835

Citations are publications that use Tocris products.

Currently there are no citations for BAY 9835. Do you know of a great paper that uses BAY 9835 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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