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Submit ReviewBAY 9835 is a potent ADAMTS7 and ADAMTS12 inhibitor (IC50 values are 6 nM and 30 nM, respectively). BAY 9835 is selective over other metalloproteases (ADAMTS4, ADAMTS5, ADAM8, ADAM10, ADAM17, MMP2, MMP12, MMP14, MMP15). BAY 9835 is the first orally bioavailable ADAMTS7 inhibitor.
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 9835 probe summary on the SGC website.
M. Wt | 493.39 |
Formula | C22H16F5N5O3 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 3032487-31-0 |
PubChem ID | 170836223 |
InChI Key | LPQXZOJIUVOCAL-NRFANRHFSA-N |
Smiles | O=C(C1=C(C2=CC=C(C=C2)C(F)(F)F)C(F)=C(C=C1)F)NC[C@@]3(C4=CC=NN4C)NC(NC3=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 49.34 | 100 |
The following data is based on the product molecular weight 493.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.03 mL | 10.13 mL | 20.27 mL |
5 mM | 0.41 mL | 2.03 mL | 4.05 mL |
10 mM | 0.2 mL | 1.01 mL | 2.03 mL |
50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
References are publications that support the biological activity of the product.
Meibom et al (2024) BAY-9835: Discovery of the first orally bioavailable ADAMTS7 inhibitor. J.Med.Chem. 67 2907 PMID: 38348661
If you know of a relevant reference for BAY 9835, please let us know.
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