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SJPYT 310

Cat. No. 8839 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective PXR antagonist
Chemical Name: N-[5-(1,1-Dimethylethyl)-2-[(1S)-1-methylbutoxy]phenyl]-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SJPYT 310

SJPYT 310 is a potent and selective PXR antagonist (IC50 values are 4 and 9 nM for binding and cellular activity, respectively). SJPYT 310 displays selectivity for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR. SJPYT 310 shows no toxicity.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Technical Data for SJPYT 310

M. Wt 464.61
Formula C27H36N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2883814-84-2
PubChem ID 171352643
InChI Key UOXKTTLWMUQDFC-SFHVURJKSA-N
Smiles CC1=C(C(NC2=C(C=CC(C(C)(C)C)=C2)O[C@@H](C)CCC)=O)N=NN1C3=C(C=CC(C)=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJPYT 310

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.46 100
ethanol 46.46 100

Preparing Stock Solutions for SJPYT 310

The following data is based on the product molecular weight 464.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.52 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for SJPYT 310

References are publications that support the biological activity of the product.

Garcia-Maldonado et al (2024) Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat.Commun. 15 4054 PMID: 38744881

Li (2022) Design and optimization of 1 H-1,2,3-Triazole-4-carboxamides as novel, potent, and selective inverse agonists and antagonists of PXR. J.Med.Chem. 65 16829 PMID: 36480704

If you know of a relevant reference for SJPYT 310, please let us know.

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Citations for SJPYT 310

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.