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Progesterone receptor membrane component 1 (Pgrmc1) ligand. Inhibits cell cycle progression and cell viability in cancer cell lines. Inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 454.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.4 mL||21.98 mL||43.96 mL|
|2.5 mM||0.88 mL||4.4 mL||8.79 mL|
|5 mM||0.44 mL||2.2 mL||4.4 mL|
|25 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the biological activity of the product.
Ahmed et al (2010) Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J.Pharmacol.Exp.Ther. 333 564 PMID: 20164297
Bashour and Wray (2012) Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1. Endocrinology. 153 4457 PMID: 22822163
Yoshitani et al (2005) A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements. Proteomics. 5 1472 PMID: 15798990
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Keywords: AG 205, AG 205 supplier, AG205, progesterone, receptor, membrane, component, 1, Pgrmc1, ligands, inhibitors, inhibits, Progesterone, Receptor, 6242, Tocris Bioscience
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Literature in this Area
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