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Description: Endogenous progesterone receptor agonist
Chemical Name: Pregn-4-ene-3,20-dione
Purity: ≥99% (HPLC)
Citations (6)

Biological Activity for Progesterone

Progesterone is an endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM).

Technical Data for Progesterone

M. Wt 314.46
Formula C21H30O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 57-83-0
PubChem ID 5994
Smiles O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](C)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Progesterone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.45 100
ethanol 31.45 100

Preparing Stock Solutions for Progesterone

The following data is based on the product molecular weight 314.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.9 mL 31.8 mL
5 mM 0.64 mL 3.18 mL 6.36 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Progesterone

Certificate of Analysis / Product Datasheet
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References for Progesterone

References are publications that support the biological activity of the product.

Dong et al (2004) Characterization of a new class of selective nonsteroidal progesterone receptor agonist. Steroids 69 201 PMID: 15072922

Jerry (2007) Roles of estrogen and progesterone in breast cancer prevention. Breast Cancer Res. 9 102 PMID: 17381827

If you know of a relevant reference for Progesterone, please let us know.

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Keywords: Progesterone, Progesterone supplier, Endogenous, progesterone, receptors, agonists, Progesterone, Receptor, 2835, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Progesterone, which is known to the State of California to cause cancer. For more information, go to

6 Citations for Progesterone

Citations are publications that use Tocris products. Selected citations for Progesterone include:

Gibson et al (2016) Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes. Sci Rep 6 19970 PMID: 26817618

Gibson et al (2018) Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age. Fertil Steril 109 728 PMID: 29397924

Gibson et al (2018) SULFATION PATHWAYS: A role for steroid sulphatase in intracrine regulation of endometrial decidualisation. J Mol Endocrinol 61 M57 PMID: 29720512

White et al (2011) The serotonin transporter, gender, and 17β OE in the development of pulmonary arterial hypertension. J Neurosci 90 373 PMID: 21177701

Do you know of a great paper that uses Progesterone from Tocris? Please let us know.

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