Megestrol Acetate

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Cat.No. 6285 - Megestrol Acetate | C24H32O4 | CAS No. 595-33-5
Description: Synthetic progesterone analog
Chemical Name: 17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
Purity: ≥98% (HPLC)

Biological Activity

Synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.

Technical Data

M. Wt 384.51
Formula C24H32O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 595-33-5
PubChem ID 11683
Smiles [H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.23 50
ethanol 7.69 20

Preparing Stock Solutions

The following data is based on the product molecular weight 384.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Zhang and Chow (2004) The effect of megestrol acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 10 5226 PMID: 15297426

Tchekmedyian et al (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer. 69 1268 PMID: 1739926

If you know of a relevant reference for Megestrol Acetate, please let us know.

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