Megestrol Acetate

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Description: Synthetic progesterone analog
Chemical Name: 17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
Purity: ≥98% (HPLC)

Biological Activity for Megestrol Acetate

Megestrol Acetate is a synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.

Compound Libraries for Megestrol Acetate

Megestrol Acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Megestrol Acetate

M. Wt 384.51
Formula C24H32O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 595-33-5
PubChem ID 11683
Smiles [H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Megestrol Acetate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.23 50
ethanol 7.69 20

Preparing Stock Solutions for Megestrol Acetate

The following data is based on the product molecular weight 384.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.2 mL 26.01 mL 52.01 mL
2.5 mM 1.04 mL 5.2 mL 10.4 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
25 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets for Megestrol Acetate

References for Megestrol Acetate

References are publications that support the biological activity of the product.

Zhang and Chow (2004) The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 10 5226 PMID: 15297426

Tchekmedyian et al (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer. 69 1268 PMID: 1739926

If you know of a relevant reference for Megestrol Acetate, please let us know.

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⚠ WARNING: This product can expose you to chemicals including Megestrol acetate, which is known to the State of California to cause cancer. For more information, go to

Citations for Megestrol Acetate

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