Megestrol Acetate

Pricing Availability Delivery Time Qty
Cat.No. 6285 - Megestrol Acetate | C24H32O4 | CAS No. 595-33-5
Description: Synthetic progesterone analog
Chemical Name: 17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.

Technical Data

M. Wt 384.51
Formula C24H32O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 595-33-5
PubChem ID 11683
InChI Key RQZAXGRLVPAYTJ-GQFGMJRRSA-N
Smiles [H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.23 50
ethanol 7.69 20

Preparing Stock Solutions

The following data is based on the product molecular weight 384.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Zhang and Chow (2004) The effect of megestrol acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 10 5226 PMID: 15297426

Tchekmedyian et al (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer. 69 1268 PMID: 1739926


If you know of a relevant reference for Megestrol Acetate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Progesterone Receptor Agonists

Keywords: Megestrol Acetate, Megestrol Acetate supplier, Megestrol, acetate, progesterone, analog, agonists, agonism, weight, gain, tumor, cancer, Progesterone, Receptor, 6285, Tocris Bioscience

Citations for Megestrol Acetate

Citations are publications that use Tocris products.

Currently there are no citations for Megestrol Acetate. Do you know of a great paper that uses Megestrol Acetate from Tocris? Please let us know.

Reviews for Megestrol Acetate

There are currently no reviews for this product. Be the first to review Megestrol Acetate and earn rewards!

Have you used Megestrol Acetate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors