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Synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 384.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.2 mL||26.01 mL||52.01 mL|
|2.5 mM||1.04 mL||5.2 mL||10.4 mL|
|5 mM||0.52 mL||2.6 mL||5.2 mL|
|25 mM||0.1 mL||0.52 mL||1.04 mL|
References are publications that support the biological activity of the product.
Zhang and Chow (2004) The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 10 5226 PMID: 15297426
Tchekmedyian et al (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer. 69 1268 PMID: 1739926
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Keywords: Megestrol Acetate, Megestrol Acetate supplier, Megestrol, acetate, progesterone, analog, agonists, agonism, weight, gain, tumor, cancer, Progesterone, Receptor, 6285, Tocris Bioscience
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Literature in this Area
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