PH 797804

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Description: Potent and selective p38α/β inhibitor
Chemical Name: (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for PH 797804

PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.

PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for PH 797804

PH 797804 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PH 797804

M. Wt 477.3
Formula C22H19BrF2N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1358027-80-1
PubChem ID 22049997
Smiles FC1=CC=C(COC2=C(Br)C(N(C3=CC(C(NC)=O)=CC=C3C)C(C)=C2)=O)C(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PH 797804

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.86 50

Preparing Stock Solutions for PH 797804

The following data is based on the product molecular weight 477.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.19 mL 20.95 mL 41.9 mL
2.5 mM 0.84 mL 4.19 mL 8.38 mL
5 mM 0.42 mL 2.1 mL 4.19 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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References for PH 797804

References are publications that support the biological activity of the product.

Hope et al (2009) Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J.Pharmacol.Exp.Ther. 331 882 PMID: 19720877

Selness et al (2011) Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg.Med.Chem.Lett. 21 4066 PMID: 21641211

If you know of a relevant reference for PH 797804, please let us know.

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Citations for PH 797804

Citations are publications that use Tocris products.

Currently there are no citations for PH 797804. Do you know of a great paper that uses PH 797804 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for PH 797804

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.