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Biological Activity for SJFδ
SJFδ is a potent and selective PROTAC ® Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data for SJFδ
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SJFδ
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SJFδ
The following data is based on the product molecular weight 1168.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||1.71 mL||8.56 mL||17.12 mL|
|2.5 mM||0.34 mL||1.71 mL||3.42 mL|
|5 mM||0.17 mL||0.86 mL||1.71 mL|
|25 mM||0.03 mL||0.17 mL||0.34 mL|
References for SJFδ
References are publications that support the biological activity of the product.
Smith et al (2019) Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat.Commun. 10 131 PMID: 30631068
If you know of a relevant reference for SJFδ, please let us know.
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Citations for SJFδ
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Targeted Protein Degradation Poster
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