EO 1428

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Cat.No. 2908 - EO 1428 | C20H16BrClN2O | CAS No. 321351-00-2
Description: Selective inhibitor of p38α and p38β2
Chemical Name: (2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)
Pathways (1)

Biological Activity for EO 1428

EO 1428 is a selective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.

Compound Libraries for EO 1428

EO 1428 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for EO 1428

M. Wt 415.71
Formula C20H16BrClN2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 321351-00-2
PubChem ID 9801969
InChI Key HDCLCHNAEZNGNV-UHFFFAOYSA-N
Smiles CC1=CC=CC=C1C(C2=CC=C(NC3=C(N)C=C(Br)C=C3)C=C2Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EO 1428

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.57 100
ethanol 20.79 50

Preparing Stock Solutions for EO 1428

The following data is based on the product molecular weight 415.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.06 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for EO 1428

References are publications that support the biological activity of the product.

Ottosen et al (2003) Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J.Med.Chem. 46 5651 PMID: 14667219


If you know of a relevant reference for EO 1428, please let us know.

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View all p38 MAPK Inhibitors

Keywords: EO 1428, EO 1428 supplier, Selective, inhibitors, inhibits, p38α, p38alpha, p38β2, p38β, p38beta2, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, EO1428, p38, 2908, Tocris Bioscience

1 Citation for EO 1428

Citations are publications that use Tocris products. Selected citations for EO 1428 include:

Jones et al (2018) Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal 11 PMID: 29511118


Do you know of a great paper that uses EO 1428 from Tocris? Please let us know.

Reviews for EO 1428

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for EO 1428

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.