NPY Receptors

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2035 BWX 46
Highly selective NPY Y5 agonist
1177 Neuropeptide Y 13-36 (porcine)
NPY Y2 receptor agonist
1153 Neuropeptide Y (human, rat)
Influences feeding and sexual behavior
1173 Neuropeptide Y (porcine)
Influences feeding and sexual behavior
3436 [D-Trp34]-Neuropeptide Y
Potent NPY Y5 agonist; orexigenic
1176 [Leu31,Pro34]-Neuropeptide Y (human, rat)
NPY Y1 receptor agonist
1168 [Leu31,Pro34]-Neuropeptide Y (porcine)
NPY Y1 receptor agonist
1154 Pancreatic Polypeptide (human)
NPY Y4 agonist; involved in gastrointestinal tract function
1365 [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide
Potent, selective NPY Y5 agonist
1618 Peptide YY (3-36)
Selective NPY Y2 receptor agonist
6288 Peptide YY (3-36) human
NPY Y2 receptor agonist

Antagonists

Cat No Product Name / Activity
2412 BIBO 3304 trifluoroacetate
Highly selective NPY Y1 receptor antagonist
2707 BIBP 3226 trifluoroacetate
Mixed NPY Y1 and NPFF receptor antagonist
1700 BIIE 0246
Potent, selective non-peptide NPY Y2 receptor antagonist
3242 BMS 193885
Potent, competitive NPY Y1 receptor antagonist
2177 BVD 10
Highly selective NPY Y1 receptor antagonist; devoid of Y4 agonist activity
2199 CGP 71683 hydrochloride
Highly selective and potent non-peptide NPY Y5 receptor antagonist
4606 CYM 9484
Potent NPY Y2 receptor antagonist
4669 GW 438014A
NPY Y5 receptor antagonist
4018 JNJ 5207787
Selective NPY Y2 receptor antagonist
1382 L-152,804
Potent, selective non-peptide NPY Y5 receptor antagonist
3562 LU AA33810
Potent NPY Y5 receptor antagonist
3677 NPY 5RA972
Potent and selective NPY Y5 antagonist
2155 NTNCB hydrochloride
Potent and selective non-peptidic NPY Y5 antagonist
2200 PD 160170
Selective non-peptide NPY Y1 receptor antagonist
3432 S 25585
Potent and selective NPY Y5 receptor antagonist
3898 SF 11
NPY Y2 receptor antagonist

Other

Cat No Product Name / Activity
1486 GR 231118
Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors
3903 Neuropeptide Y (scrambled)
Control peptide for neuropeptide Y (Cat. No. 1173)

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.

All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

External sources of pharmacological information for NPY Receptors :

Literature for NPY Receptors

GPCR

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Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
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  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Neuropeptide Y (NPY) Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Y1 Human NPY1R NM_000909 P25929
Mouse Npyr1 NM_010934 Q04573
Rat Npy1r NM_001013032 P21555
Y2 Human NPY2R NM_000910 P49146
Mouse Npy2r NM_008731 P97295
Rat Npy2r NM_023968 O70424
Y4 Human PPYR1 NM_005972 P50391
Mouse Ppyr1 NM_008919 Q61041
Rat Ppyr1 NM_031581 Q63447
Y5 Human NPY5R NM_006174 Q15761
Mouse Npy5r NM_016708 O70342
Rat Npy5r NM_012869 Q63634