LU AA33810

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Cat.No. 3562 - LU AA33810 | C19H25N3O2S3 | CAS No. 304008-29-5
Description: Potent NPY Y5 receptor antagonist
Chemical Name: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Technical Data

M. Wt 423.62
Formula C19H25N3O2S3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 304008-29-5
PubChem ID 22254068
InChI Key UWSBTSAJZMIHBL-UHFFFAOYSA-N
Smiles O=S(NC[C@H](CC4)CC[C@@H]4NC1=NC(C2=CC=CC=C2SCC3)=C3S1)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 423.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.8 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Walker et al (2009) he novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects J.Pharmacol.Exp.Ther. 328 900 PMID: 19098165


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Keywords: LUAA33810 potent NPY neuropeptide Y receptors Y5 antagonists neuropeptides NPY Receptors

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