BIIE 0246 hydrochloride

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo
Alternative Names: BIIE 0246 2HCl,BIIE0246 2HCl
Chemical Name: N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity for BIIE 0246 hydrochloride

BIIE 0246 hydrochloride is a potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.

Technical Data for BIIE 0246 hydrochloride

M. Wt 968.98
Formula C49H57N11O6.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 246146-31-6
InChI Key UESZCTPNTRZXHQ-SICTUBFJSA-N
Smiles O=C(C1=C2C=CC=C1)NC3=CC=CC=C3C2N(CC4)CCN4C(CC5(CCCC5)CC(N[C@@H](CCCNC(N)=N)C(NCCN6C(N(C7=CC=CC=C7)N(C8=CC=CC=C8)C6=O)=O)=O)=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BIIE 0246 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 96.9 100

Preparing Stock Solutions for BIIE 0246 hydrochloride

The following data is based on the product molecular weight 968.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.16 mL 10.32 mL
5 mM 0.21 mL 1.03 mL 2.06 mL
10 mM 0.1 mL 0.52 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for BIIE 0246 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for BIIE 0246 hydrochloride

References are publications that support the biological activity of the product.

Doods et al (1999) BIIE0246: a selective and high affinity neuropeptide Y Y2 receptor antagonist. Eur.J.Pharmacol. 384 R3 PMID: 10611450

Dumont et al (2000) BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y2 receptor antagonist. Br.J.Pharmacol. 129 1075 PMID: 10725255

Malmstrom et al (2001) Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y2 receptor antagonist, in vivo. Br.J.Pharmacol. 133 1073 PMID: 11487518


If you know of a relevant reference for BIIE 0246 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NPY Receptor Antagonists

Keywords: BIIE 0246 hydrochloride, BIIE 0246 hydrochloride supplier, BIIE0246, dihydrochloride, 2HCl, Potent, selective, non-peptide, NPY, Y2, antagonists, Neuropeptide, Y, Receptors, neuropeptides, BIIE, 0246, 7377, Tocris Bioscience

2 Citations for BIIE 0246 hydrochloride

Citations are publications that use Tocris products. Selected citations for BIIE 0246 hydrochloride include:

Yue et al (2022) mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight 7 PMID: 36194480

Sanchez et al (2021) Photo-induced receptor confinement drives ligand-independent GPCR signaling. Science 371 PMID: 33632896


Do you know of a great paper that uses BIIE 0246 hydrochloride from Tocris? Please let us know.

Reviews for BIIE 0246 hydrochloride

There are currently no reviews for this product. Be the first to review BIIE 0246 hydrochloride and earn rewards!

Have you used BIIE 0246 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.