CYM 9484

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Description: Potent NPY Y2 receptor antagonist
Chemical Name: N-[4-[(Dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for CYM 9484

CYM 9484 is a potent neuropeptide Y (NPY) Y2 receptor antagonist (IC50 = 19 nM).

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data for CYM 9484

M. Wt 509.63
Formula C27H31N3O3S2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1383478-94-1
PubChem ID 66561564
Smiles OC(C2=CC=CC=C2)(C3=CC=CC=C3)C1CCN(C(NC4=CC=C(S(=O)(N(C)C)=O)C=C4)=S)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CYM 9484

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.96 100

Preparing Stock Solutions for CYM 9484

The following data is based on the product molecular weight 509.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.81 mL 19.62 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for CYM 9484

Certificate of Analysis / Product Datasheet
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References for CYM 9484

References are publications that support the biological activity of the product.

Mittapalli et al (2012) Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 22 3916 PMID: 22607676

If you know of a relevant reference for CYM 9484, please let us know.

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Keywords: CYM 9484, CYM 9484 supplier, CYM9484, neuropeptides, Y, NPY, Y2, antagonists, potent, Receptors, 4606, Tocris Bioscience

1 Citation for CYM 9484

Citations are publications that use Tocris products. Selected citations for CYM 9484 include:

Jaroslaw et al (2020) Inflammation changes the expression of neuropeptide Y receptors in the pig myometrium and their role in the uterine contractility. PLoS One 15 e0236044 PMID: 32649683

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.