Neuropeptide Y (human, rat)

Pricing Availability Delivery Time Qty
Cat.No. 1153 - Neuropeptide Y (human, rat) | Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 | CAS No. 90880-35-6
Description: Influences feeding and sexual behavior
Alternative Names: NPY (human, rat)
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Widely distributed endogenous neuropeptide involved in the control of food intake, sexual behavior and blood pressure.

Technical Data

M. Wt 4271.7
Formula C189H285N55O57S
Sequence YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

(Modifications: Tyr-36 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 90880-35-6
PubChem ID 24868177
InChI Key XKWCTHKJQNUFOQ-HRPSIEBRSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1.50 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 4271.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.23 mL 1.17 mL 2.34 mL
5 mM 0.05 mL 0.23 mL 0.47 mL
10 mM 0.02 mL 0.12 mL 0.23 mL
50 mM 0 mL 0.02 mL 0.05 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Allen et al (1987) Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue. Proc.Natl.Acad.Sci.U.S.A. 84 2532 PMID: 3031687

Michel et al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761

Minth et al (1984) Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine. Proc.Natl.Acad.Sci.U.S.A. 81 4577 PMID: 6589611


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Keywords: Neuropeptide Y (human, rat), Neuropeptide Y (human, rat) supplier, Influences, feeding, sexual, behavior, Neuropeptide, Y, Receptors, NPY, agonists, NeuropeptideY, (human), neuropeptides, (human,, rat), 1153, Tocris Bioscience

1 Citation for Neuropeptide Y (human, rat)

Citations are publications that use Tocris products. Selected citations for Neuropeptide Y (human, rat) include:

Singer et al (2013) Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation. PLoS One 8 e57929 PMID: 23472120


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Field Recording and Bath Application of NPY
By Aundrea Bartley on 01/05/2018
Assay Type: In Vitro
Species: Mouse

Bath application of NPY to acute hippocampal slices and recorded field responses

We precoated the tubing with 0.1 mg/ml of BSA to prevent issues of NPY sticking to the tubing. BSA cannot be added directly to the recording solution because of issues that arise during oxygenation.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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