SF 11

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Cat.No. 3898 - SF 11 | C27H30N2O2S | CAS No. 443292-81-7
Description: NPY Y2 receptor antagonist
Chemical Name: N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for SF 11

SF 11 is a NPY Y2 antagonist (IC50 = 199 nM). Displays no affinity for Y1 receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.

Compound Libraries for SF 11

SF 11 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SF 11

M. Wt 446.6
Formula C27H30N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 443292-81-7
PubChem ID 2936384
InChI Key PMEQBGAGFZDWQX-UHFFFAOYSA-N
Smiles S=C(N2CCC(C(C4=CC=CC=C4)(O)C3=CC=CC=C3)CC2)NC1=CC=C(OCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SF 11

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.66 100
ethanol 22.33 50

Preparing Stock Solutions for SF 11

The following data is based on the product molecular weight 446.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.39 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Reconstitution Calculator

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References for SF 11

References are publications that support the biological activity of the product.

Brothers et al (2010) Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol. 77 46 PMID: 19837904

Domin et al (2019) Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem.Neurosci. 10 3454 PMID: 31267743


If you know of a relevant reference for SF 11, please let us know.

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Keywords: SF 11, SF 11 supplier, neuropeptide, Y, NPY, Y2, antagonists, SF11, neuropeptides, Receptors, 3898, Tocris Bioscience

1 Citation for SF 11

Citations are publications that use Tocris products. Selected citations for SF 11 include:

Domin et al (2019) Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem Neurosci 10 3454 PMID: 31267743


Do you know of a great paper that uses SF 11 from Tocris? Please let us know.

Reviews for SF 11

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