SF 11

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Cat.No. 3898 - SF 11 | C27H30N2O2S | CAS No. 443292-81-7
Description: NPY Y2 receptor antagonist
Chemical Name: N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

NPY Y2 antagonist (IC50 = 199 nM). Displays no affinity for Y1 receptor at concentrations up to 35 μM. Causes significant lethality in mice. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 446.6
Formula C27H30N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 443292-81-7
PubChem ID 2936384
InChI Key PMEQBGAGFZDWQX-UHFFFAOYSA-N
Smiles S=C(N2CCC(C(C4=CC=CC=C4)(O)C3=CC=CC=C3)CC2)NC1=CC=C(OCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.66 100
ethanol 22.33 50

Preparing Stock Solutions

The following data is based on the product molecular weight 446.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.39 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Brothers et al (2010) Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol. 77 46 PMID: 19837904


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Keywords: neuropeptide Y NPY Y2 antagonists SF11 neuropeptides NPY Receptors

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Pathways for SF 11

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