SF 11

Pricing Availability   Qty
Description: NPY Y2 receptor antagonist
Chemical Name: N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for SF 11

SF 11 is an NPY Y2 antagonist (IC50 = 199 nM). Displays no affinity for Y1 receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.

Compound Libraries for SF 11

SF 11 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SF 11

M. Wt 446.6
Formula C27H30N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 443292-81-7
PubChem ID 2936384
Smiles S=C(N2CCC(C(C4=CC=CC=C4)(O)C3=CC=CC=C3)CC2)NC1=CC=C(OCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SF 11

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.66 100
ethanol 22.33 50

Preparing Stock Solutions for SF 11

The following data is based on the product molecular weight 446.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.39 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

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References for SF 11

References are publications that support the biological activity of the product.

Brothers et al (2010) Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol. 77 46 PMID: 19837904

Domin et al (2019) Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem.Neurosci. 10 3454 PMID: 31267743

If you know of a relevant reference for SF 11, please let us know.

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Keywords: SF 11, SF 11 supplier, neuropeptide, Y, NPY, Y2, antagonists, SF11, neuropeptides, Receptors, 3898, Tocris Bioscience

1 Citation for SF 11

Citations are publications that use Tocris products. Selected citations for SF 11 include:

Domin et al (2019) Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem Neurosci 10 3454 PMID: 31267743

Do you know of a great paper that uses SF 11 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.