[Leu31,Pro34]-Neuropeptide Y (human, rat)

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Cat.No. 1176 - [Leu31,Pro34]-Neuropeptide Y (human, rat) | Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 | CAS No. 132699-73-1
Description: NPY Y1 receptor agonist
Alternative Names: [Leu31,Pro34]-NPY (human)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.

Technical Data

M. Wt 4241
Formula C189H284N54O56S
Sequence YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY

(Modifications: Tyr-36 = C-terminal amide)

Storage Store at -20°C
CAS Number 132699-73-1
PubChem ID 24868223
InChI Key MPWANDCMSKOYBR-MJWITIMHSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911

Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182 PMID: 2153286

Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507 PMID: 9723965

Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761


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Keywords: [Leu31,Pro34]-Neuropeptide Y (human, rat), [Leu31,Pro34]-Neuropeptide Y (human, rat) supplier, NPY, Y1, receptor, agonists, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (human,, rat), neuropeptides, [Leu31,Pro34]-NPY, (human), 1176, Tocris Bioscience

2 Citations for [Leu31,Pro34]-Neuropeptide Y (human, rat)

Citations are publications that use Tocris products. Selected citations for [Leu31,Pro34]-Neuropeptide Y (human, rat) include:

Malet (2017) Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury. Peptides 92 38 PMID: 28465077

Yu et al (2016) Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling. Int J Mol Sci 17 PMID: 28009825


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