[Leu31,Pro34]-Neuropeptide Y (human, rat)

Pricing Availability   Qty
Description: NPY Y1 receptor agonist
Alternative Names: [Leu31,Pro34]-NPY (human)
Purity: ≥95% (HPLC)
Citations (3)
Reviews (1)
Literature (1)

Biological Activity

[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.

Technical Data

M. Wt 4241
Formula C189H284N54O56S

(Modifications: Tyr-36 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 132699-73-1
PubChem ID 24868223
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911

Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182 PMID: 2153286

Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507 PMID: 9723965

Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761

If you know of a relevant reference for [Leu31,Pro34]-Neuropeptide Y (human, rat), please let us know.

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Keywords: [Leu31,Pro34]-Neuropeptide Y (human, rat), [Leu31,Pro34]-Neuropeptide Y (human, rat) supplier, NPY, Y1, receptor, agonists, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (human,, rat), neuropeptides, [Leu31,Pro34]-NPY, (human), 1176, Tocris Bioscience

3 Citations for [Leu31,Pro34]-Neuropeptide Y (human, rat)

Citations are publications that use Tocris products. Selected citations for [Leu31,Pro34]-Neuropeptide Y (human, rat) include:

Maymon et al (2019) Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. Neuropharmacology 162 PMID: 31622603

Yu et al (2016) Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling. Int J Mol Sci 17 PMID: 28009825

Malet (2017) Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury. Peptides 92 38 PMID: 28465077

Do you know of a great paper that uses [Leu31,Pro34]-Neuropeptide Y (human, rat) from Tocris? Please let us know.

Reviews for [Leu31,Pro34]-Neuropeptide Y (human, rat)

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[Leu31,Pro34]-Neuropeptide Y current in spinal dorsal horn neuron.
By Allen Dickie on 03/24/2023
Assay Type: Ex Vivo
Species: Mouse

Whole cell patch clamp recording (voltage clamp) from spinal dorsal horn interneuron, in ex vivo slice preparation, in response to bath application of [Leu31,Pro34]-Neuropeptide Y (300 nM), in the presence of TTX, bicuculline and strychnine.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.