BIBP 3226 trifluoroacetate

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Description: Mixed NPY Y1 and NPFF receptor antagonist
Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate
Purity: ≥98% (HPLC)
Citations (14)
Literature (1)

Biological Activity for BIBP 3226 trifluoroacetate

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Important Information for BIBP 3226 trifluoroacetate

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis

Technical Data for BIBP 3226 trifluoroacetate

M. Wt 473.57 (Free Base)
Formula C27H31N5O3.xCF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513845
Smiles OC1=CC=C(CNC([C@H](NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CCCNC(N)=N)=O)C=C1.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BIBP 3226 trifluoroacetate

Solubility Soluble to 1 mg/ml in water and to 50 mg/ml in DMSO

Product Datasheets for BIBP 3226 trifluoroacetate

Certificate of Analysis / Product Datasheet
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References for BIBP 3226 trifluoroacetate

References are publications that support the biological activity of the product.

Kask et al (1996) Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with D.pam. Eur.J.Pharmacol. 317 R3 PMID: 8997632

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1 PMID: 11325787

Fang et al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207 PMID: 16762456

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Keywords: BIBP 3226 trifluoroacetate, BIBP 3226 trifluoroacetate supplier, Mixed, NPFF, NPY, Y1, receptor, antagonists, Receptors, Neuropeptide, FF/AF, Y, BIBP3226, trifluoroacetate, npffr1, npffr2, npff1, npff2, neuropeptides, 2707, Tocris Bioscience

14 Citations for BIBP 3226 trifluoroacetate

Citations are publications that use Tocris products. Selected citations for BIBP 3226 trifluoroacetate include:

Santos-Carvalho et al (2013) Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Proc Natl Acad Sci U S A 4 e636 PMID: 23681231

Businaro et al (2018) Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep 8 14365 PMID: 30254326

Sparrow et al (2012) Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Proc Natl Acad Sci U S A 37 1409 PMID: 22218088

Reidelberger et al (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab 304 E944 PMID: 23482449

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582

Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun 8 189 PMID: 28775269

Acton et al (2019) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep 28 625 PMID: 31315043

Son et al (2011) Involvement of neuropeptide Y and its Y1 and Y5 receptors in maintaining self-renewal and proliferation of human embryonic stem cells. J Cell Mol Med 15 152 PMID: 19874423

Yi et al (2012) Glucocorticoid signaling in the arcuate nucleus modulates hepatic Ins sensitivity. Diabetes 61 339 PMID: 22210324

Novielli et al (2012) Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS One 7 e46659 PMID: 23071607

Pleil et al (2012) Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology 62 1777 PMID: 22182779

Aveleira et al (2015) Neuropeptide Y stimulates autophagy in hypothalamic neurons. Cell Death Dis 112 E1642 PMID: 25775546

Martins et al (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro 7 PMID: 26311075

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.