BIBP 3226 trifluoroacetate

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Cat.No. 2707 - BIBP 3226 trifluoroacetate | C27H31N5O3.2CF3CO2H
Description: Mixed NPY Y1 and NPFF receptor antagonist
Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide ditrifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Literature

Biological Activity

Mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Technical Data

M. Wt 701.61
Formula C27H31N5O3.2CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513845
InChI Key FSBMUMHPXBMVJF-MQWQBNKOSA-N
Smiles OC1=CC=C(CNC([C@H](NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CCCNC(N)=N)=O)C=C1.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 70.16 100
water 7.02 10mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 701.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.43 mL 7.13 mL 14.25 mL
5 mM 0.29 mL 1.43 mL 2.85 mL
10 mM 0.14 mL 0.71 mL 1.43 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kask et al (1996) Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur.J.Pharmacol. 317 R3 PMID: 8997632

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1 PMID: 11325787

Fang et al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207 PMID: 16762456


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View Related Products by Product Action

View all NPY Receptor Antagonists

Keywords: Mixed NPFF NPY Y1 receptor antagonists Receptors Neuropeptide FF/AF Y BIBP3226 trifluoroacetate npffr1 npffr2 npff1 npff2 neuropeptides NPY Receptors

10 Citations for BIBP 3226 trifluoroacetate

Citations are publications that use Tocris products. Selected citations for BIBP 3226 trifluoroacetate include:

Martins et al (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro 7 PMID: 26311075

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534

Aveleira et al (2015) Neuropeptide Y stimulates autophagy in hypothalamic neurons. Cell Death Dis 112 E1642 PMID: 25775546

Reidelberger et al (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab 304 E944 PMID: 23482449

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582

Santos-Carvalho et al (2013) Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Proc Natl Acad Sci U S A 4 e636 PMID: 23681231

Yi et al (2012) Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 61 339 PMID: 22210324

Novielli et al (2012) Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS One 7 e46659 PMID: 23071607

Pleil et al (2012) Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology 62 1777 PMID: 22182779

Sparrow et al (2012) Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Proc Natl Acad Sci U S A 37 1409 PMID: 22218088


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