Eplerenone

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Cat.No. 2397 - Eplerenone | C24H30O6 | CAS No. 107724-20-9
Description: Selective mineralocorticoid receptor antagonist
Alternative Names: Inspra, Epoxymexrenone
Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data

M. Wt 414.5
Formula C24H30O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 107724-20-9
PubChem ID 443872
InChI Key JUKPWJGBANNWMW-VWBFHTRKSA-N
Smiles O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.14 10

Preparing Stock Solutions

The following data is based on the product molecular weight 414.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.13 mL 120.63 mL 241.25 mL
0.5 mM 4.83 mL 24.13 mL 48.25 mL
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650 PMID: 2949071

McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190 PMID: 11714095


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View all Mineralocorticoid Receptor Antagonists

Keywords: Eplerenone, Eplerenone supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Inspra, Epoxymexrenone, Mineralocorticoid, Receptor, 2397, Tocris Bioscience

1 Citation for Eplerenone

Citations are publications that use Tocris products. Selected citations for Eplerenone include:

Urbanet et al (2010) Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. Purinergic Signal 95 4037 PMID: 20484481


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Literature in this Area

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