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Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 414.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||24.13 mL||120.63 mL||241.25 mL|
|0.5 mM||4.83 mL||24.13 mL||48.25 mL|
|1 mM||2.41 mL||12.06 mL||24.13 mL|
|5 mM||0.48 mL||2.41 mL||4.83 mL|
References are publications that support the biological activity of the product.
De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650 PMID: 2949071
McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190 PMID: 11714095
If you know of a relevant reference for Eplerenone, please let us know.
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Keywords: Eplerenone, Eplerenone supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Inspra, Epoxymexrenone, Mineralocorticoid, Receptor, 2397, Tocris Bioscience
2 Citations for Eplerenone
Citations are publications that use Tocris products. Selected citations for Eplerenone include:
Ibrahim et al (2018) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci 12 453 PMID: 30524245
Urbanet et al (2010) Analysis of Ins sensitivity in adipose tissue of patients with primary aldosteronism. Purinergic Signal 95 4037 PMID: 20484481
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Literature in this Area
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