Eplerenone

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Cat.No. 2397 - Eplerenone | C24H30O6 | CAS No. 107724-20-9
Description: Selective mineralocorticoid receptor antagonist
Alternative Names: Inspra, Epoxymexrenone
Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data

M. Wt 414.5
Formula C24H30O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 107724-20-9
PubChem ID 443872
InChI Key JUKPWJGBANNWMW-VWBFHTRKSA-N
Smiles O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.14 10

Preparing Stock Solutions

The following data is based on the product molecular weight 414.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650 PMID: 2949071

McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190 PMID: 11714095


If you know of a relevant reference for Eplerenone, please let us know.

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View all Mineralocorticoid Receptor Antagonists

Keywords: Selective mineralocorticoid receptor antagonists Aldosterone Receptors Inspra Epoxymexrenone Mineralocorticoid Receptor

1 Citation for Eplerenone

Citations are publications that use Tocris products. Selected citations for Eplerenone include:

Urbanet et al (2010) Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. Purinergic Signal 95 4037 PMID: 20484481


Do you know of a great paper that uses Eplerenone from Tocris? If so please let us know.

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Reviews

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Pathways for Eplerenone

Protocols

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