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Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
Spironolactone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 416.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.4 mL||12 mL||24.01 mL|
|5 mM||0.48 mL||2.4 mL||4.8 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075
Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironola. Clin.Cardiol. 31 153 PMID: 18404673
Ye et al (2009) Contrasting effects of epler. and spironola. on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35 PMID: 18819053
If you know of a relevant reference for Spironolactone, please let us know.
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Citations are publications that use Tocris products. Selected citations for Spironolactone include:
Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222
Thai et al (2013) Effects of acute restraint stress on set-shifting and reversal learning in male rats. Cogn Affect Behav Neurosci 13 164 PMID: 23055093
Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull 124 222 PMID: 27208730
Do you know of a great paper that uses Spironolactone from Tocris? Please let us know.
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