Spironolactone

Pricing Availability Delivery Time Qty
Cat.No. 2968 - Spironolactone | C24H32O4S | CAS No. 52-01-7
Description: Mineralocorticoid receptor antagonist
Alternative Names: SC 9420, Aldactone
Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Compound Libraries

Spironolactone is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 416.57
Formula C24H32O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 52-01-7
PubChem ID 5833
InChI Key LXMSZDCAJNLERA-ZHYRCANASA-N
Smiles O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.66 100
ethanol 20.83 50

Preparing Stock Solutions

The following data is based on the product molecular weight 416.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075

Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153 PMID: 18404673

Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35 PMID: 18819053


If you know of a relevant reference for Spironolactone, please let us know.

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View all Mineralocorticoid Receptor Antagonists

Keywords: Anti-Androgen AntiAndrogen inhibits inhibitors steroid hormone biosynthesis MR antagonists Mineralocorticoid receptor Dihydrotestosterone Receptors Androgen Aldosterone SC9420 SC 9420 Aldactone Mineralocorticoid Receptor

1 Citation for Spironolactone

Citations are publications that use Tocris products. Selected citations for Spironolactone include:

Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222


Do you know of a great paper that uses Spironolactone from Tocris? If so please let us know.

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Reviews

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Pathways for Spironolactone

Protocols

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