Spironolactone

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Cat.No. 2968 - Spironolactone | C24H32O4S | CAS No. 52-01-7
Description: Mineralocorticoid receptor antagonist
Alternative Names: SC 9420, Aldactone
Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Compound Libraries

Spironolactone is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 416.57
Formula C24H32O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 52-01-7
PubChem ID 5833
InChI Key LXMSZDCAJNLERA-ZHYRCANASA-N
Smiles O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.66 100
ethanol 20.83 50

Preparing Stock Solutions

The following data is based on the product molecular weight 416.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075

Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironola. Clin.Cardiol. 31 153 PMID: 18404673

Ye et al (2009) Contrasting effects of epler. and spironola. on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35 PMID: 18819053


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View all Mineralocorticoid Receptor Antagonists

Keywords: Spironolactone, Spironolactone supplier, Anti-Androgen, AntiAndrogen, inhibits, inhibitors, steroid, hormone, biosynthesis, MR, antagonists, Mineralocorticoid, receptor, Dihydrotestosterone, Receptors, Androgen, Aldosterone, SC9420, SC, 9420, Aldactone, Receptor, 2968, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 Citations for Spironolactone

Citations are publications that use Tocris products. Selected citations for Spironolactone include:

Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222

Thai et al (2013) Effects of acute restraint stress on set-shifting and reversal learning in male rats. Cogn Affect Behav Neurosci 13 164 PMID: 23055093

Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull 124 222 PMID: 27208730


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Literature in this Area

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