Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 416.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.4 mL||12 mL||24.01 mL|
|5 mM||0.48 mL||2.4 mL||4.8 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075
Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153 PMID: 18404673
Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35 PMID: 18819053
If you know of a relevant reference for Spironolactone, please let us know.
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Keywords: Anti-Androgen AntiAndrogen inhibits inhibitors steroid hormone biosynthesis MR antagonists Mineralocorticoid receptor Dihydrotestosterone Receptors Androgen Aldosterone SC9420 SC 9420 Aldactone Mineralocorticoid Receptor
1 Citation for Spironolactone
Citations are publications that use Tocris products. Selected citations for Spironolactone include:
Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222
Do you know of a great paper that uses Spironolactone from Tocris? If so please let us know.