Pricing Availability   Qty
Description: Mineralocorticoid receptor antagonist
Alternative Names: SC 9420,Aldactone
Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for Spironolactone

Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Compound Libraries for Spironolactone

Spironolactone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Spironolactone

M. Wt 416.57
Formula C24H32O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 52-01-7
PubChem ID 5833
Smiles O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Spironolactone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.66 100
ethanol 20.83 50

Preparing Stock Solutions for Spironolactone

The following data is based on the product molecular weight 416.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Spironolactone

Certificate of Analysis / Product Datasheet
Select another batch:

References for Spironolactone

References are publications that support the biological activity of the product.

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075

Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironola. Clin.Cardiol. 31 153 PMID: 18404673

Ye et al (2009) Contrasting effects of epler. and spironola. on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35 PMID: 18819053

If you know of a relevant reference for Spironolactone, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Mineralocorticoid Receptor Antagonists

Keywords: Spironolactone, Spironolactone supplier, Anti-Androgen, AntiAndrogen, inhibits, inhibitors, steroid, hormone, biosynthesis, MR, antagonists, Mineralocorticoid, receptor, Dihydrotestosterone, Receptors, Androgen, Aldosterone, SC9420, SC, 9420, Aldactone, Receptor, 2968, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 Citations for Spironolactone

Citations are publications that use Tocris products. Selected citations for Spironolactone include:

Thai et al (2013) Effects of acute restraint stress on set-shifting and reversal learning in male rats. Cogn Affect Behav Neurosci 13 164 PMID: 23055093

Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull 124 222 PMID: 27208730

Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222

Do you know of a great paper that uses Spironolactone from Tocris? Please let us know.

Reviews for Spironolactone

There are currently no reviews for this product. Be the first to review Spironolactone and earn rewards!

Have you used Spironolactone?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review