Mas-related G protein-coupled receptors (MRGPRs) are a family of orphan GPCRs, subdivided into nine separate subfamilies (A-H and X). This receptor family is important in pain, temperature sensation and itch.
Mas-Related G Protein-Coupled Receptors Agonists |
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Cat. No. | Product Name / Activity |
1763 | BAM (8-22) |
Potent MRGPRX1 agonist | |
3374 | Cortistatin 14 |
Endogenous neuropeptide; binds MRGPRX2, sst1 - sst5 and ghrelin receptor | |
4231 | Nateglinide |
MRGPRX4 agonist; also Kir6 (KATP) blocker | |
3137 | Neuropeptide FF |
MRGPRA agonist; also antiopioid neuropeptide; endogenous NPFF1 and NPFF2 agonist | |
6551 | PAMP-12 (human, porcine) |
Potent MRGPRX2 agonist | |
6552 | PAMP-20 (human) |
MRGPRX2 agonist; also non-competitive nAChR antagonist | |
5473 | PMX 53 |
MRGPRX2 agonist; also potent C5a receptor antagonist | |
6351 | (R)-ZINC 3573 |
MRGPRX2 agonist | |
Mas-Related G Protein-Coupled Receptors Antagonists |
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Cat. No. | Product Name / Activity |
6642 | QWF |
MRGPRX2 antagonist; also NK1 receptor antagonist | |
Mas-Related G Protein-Coupled Receptors Modulators |
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Cat. No. | Product Name / Activity |
5738 | ML 382 |
MRGPRX1 positive allosteric modulator | |
Controls |
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Cat. No. | Product Name / Activity |
6352 | (S)-ZINC 3573 |
Negative control for (R)-ZINC 3573 |
Mas-related G protein-coupled receptors (MRGPRs) are a family of orphan GPCRs, subdivided into nine separate subfamilies (A-H and X). They are found in mammalian species, with families A, B, C and H present only in rodents, the X subfamily only in primates, including humans, and families D to G conserved across mammalian species. The MRGPRX family consists of four distinct receptors: MRGPRX1 was previously known as sensory neuron-specific receptor (SNSR) 4 and MRGPRX3 was previously named SNSR1.
MRGPRs are expressed in small-diameter somatosensory neurons of the dorsal root ganglion, MRGPRD to H are also expressed in other neurons, as well as bladder, testis, uterus, arteries, intestines and adrenal glands, and MRGPRX1 and 2 are also expressed in mast cells. This receptor family is important in pain, temperature sensation and itch. While no MRGPRs have officially been deorphanized several endogenous and exogenous compounds are known to be ligands for certain receptors in this family.
Tocris offers the following scientific literature for Mas-Related G Protein-Coupled Receptors to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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MAS related GPR family member D | Human | MRGPRD | NM_198923 | Q8TDS7 |
Mouse | Mrgprd | NM_203490 | Q91ZB8 | |
Rat | Mrgprd | NM_001001506 | Q7TN41 | |
MAS related GPR family member E | Human | MRGPRE | NM_001039165 | Q86SM8 |
Mouse | Mrgpre | NM_175534 | Q91ZB7 | |
Rat | Mrgpre | NM_001002288 | Q7TN40 | |
MAS related GPR family member F | Human | MRGPRF | NM_145015 | Q96AM1 |
Mouse | Mrgprf | NM_145379 | Q8VCJ6 | |
Rat | Mrgprf | NM_153722 | P23749 | |
MAS related GPR family member G | Human | MRGPRG | NM_001164377 | Q86SM5 |
Mouse | Mrgprg | NM_203492 | Q91ZB5 | |
Rat | Mrgprg | NM_203470 | Q7TN39 | |
MAS related GPR family member X1 | Human | MRGPRX1 | NM_147199 | Q96LB2 |
Mouse | Mrgprb2 | NM_175531 | Q3KNA1 | |
Rat | Mrgprx1 | XM_017590539 | XP_017446028 | |
MAS related GPR family member X2 | Human | MRGPRX2 | NM_147199 | Q96LB2 |
Mouse | Mrgprb1 | NM_205810 | Q3UG61 | |
Rat | Mrgprx2 | NM_001002280 | Q7TN48 | |
MAS related GPR family member X3 | Human | MRGPRX3 | NM_054031 | Q96LB0 |
Mouse | Mrgpra1 | NM_153095 | Q91WW5 | |
Rat | Mrgprx3 | NM_145787 | Q7TN49 | |
MAS related GPR family member X4 | Human | MRGPRX4 | NM_054032 | Q96LA9 |
Mouse | Mrgprx1 | NM_207540 | Q8CIP3 | |
Rat | Mrgprx4 | NM_172158 | Q8R4G1 |