Mas-Related G Protein-Coupled Receptors

Mas-related G protein-coupled receptors (MRGPRs) are a family of orphan GPCRs, subdivided into nine separate subfamilies (A-H and X). This receptor family is important in pain, temperature sensation and itch.

Products
Background
Literature
Gene Data

Agonists

Cat. No. Product Name / Activity
0206 β-Alanine
MRGPRD agonist; also GABA uptake inhibitor (GAT-2 and -3) and glycine receptor agonist
1763 BAM (8-22)
Potent MRGPRX1 agonist
1650 BAM 22P
MRGPRX1 agonist; also opioid receptor agonist
3374 Cortistatin 14
Endogenous neuropeptide; binds MRGPRX2, sst1 - sst5 and ghrelin receptor
4231 Nateglinide
MRGPRX4 agonist; also Kir6 (KATP) blocker
1928 Neuropeptide AF (human)
MRGPRA agonist; also endogenous NPFF1 and NPFF2 agonist and antiopioid neuropeptide
3137 Neuropeptide FF
MRGPRA agonist; also antiopioid neuropeptide; endogenous NPFF1 and NPFF2 agonist
6551 PAMP-12 (human, porcine)
Potent MRGPRX2 agonist
6552 PAMP-20 (human)
MRGPRX2 agonist; also non-competitive nAChR antagonist
5473 PMX 53
MRGPRX2 agonist; also potent C5a receptor antagonist
6351 (R)-ZINC 3573
MRGPRX2 agonist

Antagonists

Cat. No. Product Name / Activity
6642 QWF
MRGPRX2 antagonist; also NK1 receptor antagonist

Modulators

Cat. No. Product Name / Activity
5738 ML 382
MRGPRX1 positive allosteric modulator

Controls

Cat. No. Product Name / Activity
6352 (S)-ZINC 3573
Negative control for (R)-ZINC 3573

Mas-related G protein-coupled receptors (MRGPRs) are a family of orphan GPCRs, subdivided into nine separate subfamilies (A-H and X). They are found in mammalian species, with families A, B, C and H present only in rodents, the X subfamily only in primates, including humans, and families D to G conserved across mammalian species. The MRGPRX family consists of four distinct receptors: MRGPRX1 was previously known as sensory neuron-specific receptor (SNSR) 4 and MRGPRX3 was previously named SNSR1.

MRGPRs are expressed in small-diameter somatosensory neurons of the dorsal root ganglion, MRGPRD to H are also expressed in other neurons, as well as bladder, testis, uterus, arteries, intestines and adrenal glands, and MRGPRX1 and 2 are also expressed in mast cells. This receptor family is important in pain, temperature sensation and itch. While no MRGPRs have officially been deorphanized several endogenous and exogenous compounds are known to be ligands for certain receptors in this family.

External sources of pharmacological information for Mas-Related G Protein-Coupled Receptors :

    Literature for Mas-Related G Protein-Coupled Receptors

    Tocris offers the following scientific literature for Mas-Related G Protein-Coupled Receptors to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
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    Pain

    Pain Research Product Guide

    A collection of over 250 products for pain research, the guide includes research tools for the study of:

    • Nociception
    • Ion Channels
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    • Intracellular Signaling
    Pain

    Pain Poster

    Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

    Mas-Related G Protein-Coupled Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    MAS related GPR family member D Human MRGPRD NM_198923 Q8TDS7
    Mouse Mrgprd NM_203490 Q91ZB8
    Rat Mrgprd NM_001001506 Q7TN41
    MAS related GPR family member E Human MRGPRE NM_001039165 Q86SM8
    Mouse Mrgpre NM_175534 Q91ZB7
    Rat Mrgpre NM_001002288 Q7TN40
    MAS related GPR family member F Human MRGPRF NM_145015 Q96AM1
    Mouse Mrgprf NM_145379 Q8VCJ6
    Rat Mrgprf NM_153722 P23749
    MAS related GPR family member G Human MRGPRG NM_001164377 Q86SM5
    Mouse Mrgprg NM_203492 Q91ZB5
    Rat Mrgprg NM_203470 Q7TN39
    MAS related GPR family member X1 Human MRGPRX1 NM_147199 Q96LB2
    Mouse Mrgprb2 NM_175531 Q3KNA1
    Rat Mrgprx1 XM_017590539 XP_017446028
    MAS related GPR family member X2 Human MRGPRX2 NM_147199 Q96LB2
    Mouse Mrgprb1 NM_205810 Q3UG61
    Rat Mrgprx2 NM_001002280 Q7TN48
    MAS related GPR family member X3 Human MRGPRX3 NM_054031 Q96LB0
    Mouse Mrgpra1 NM_153095 Q91WW5
    Rat Mrgprx3 NM_145787 Q7TN49
    MAS related GPR family member X4 Human MRGPRX4 NM_054032 Q96LA9
    Mouse Mrgprx1 NM_207540 Q8CIP3
    Rat Mrgprx4 NM_172158 Q8R4G1