(R)-ZINC 3573

Pricing Availability   Qty
Description: MRGPRX2 agonist
Chemical Name: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
Purity: ≥98% (HPLC)

Biological Activity for (R)-ZINC 3573

(R)-ZINC 3573 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM), which displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. (R)-ZINC 3573 induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.

Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.

External Portal Information for (R)-ZINC 3573

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of (R)-ZINC 3573 is reviewed on chemicalprobes.org and the SGC website.

Compound Libraries for (R)-ZINC 3573

(R)-ZINC 3573 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (R)-ZINC 3573

M. Wt 307.4
Formula C18H21N5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2089389-15-9
PubChem ID 95882507
Smiles CN([C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-ZINC 3573

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 30.74 100
DMSO 30.74 100

Preparing Stock Solutions for (R)-ZINC 3573

The following data is based on the product molecular weight 307.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets for (R)-ZINC 3573

References for (R)-ZINC 3573

References are publications that support the biological activity of the product.

Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109

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Citations for (R)-ZINC 3573

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