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QWF

Cat. No. 6642 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: MRGPRX2 antagonist; also NK1 receptor antagonist
Purity: ≥90% (HPLC)
Datasheet
Citations (1)
Reviews
Protocols (1)
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for QWF

QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

For more information about how QWF may be used, see our protocol:

3D Culture of Lung Alveolar Cells

Technical Data for QWF

M. Wt 697.78
Formula C38H43N5O8
Sequence QWF

(Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl)
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 126088-82-2
PubChem ID 336446954
InChI Key ZFZOHFAASQHWER-NCRUWMDKNA-N
Smiles CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for QWF

Solubility Soluble to 10 mg/ml in DMSO

Product Datasheets for QWF

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for QWF

References are publications that support the biological activity of the product.

Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID: 1375965

Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID: 27734033

If you know of a relevant reference for QWF, please let us know.

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Keywords: QWF, QWF supplier, substance, P, antagonist, antagonism, NK1R, neurokinin, 1, mas-related, GPCR, X2, MRGPRX2, mast, cell, degranulation, SP, MRGX2, Mas-related, G, Protein-Coupled, Receptors, NK1, Receptor, 6642, Tocris Bioscience

1 Citation for QWF

Citations are publications that use Tocris products. Selected citations for QWF include:

Song and Shim et al (2021) Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice Biomol Ther (Seoul) 30(1) 38 PMID: 34263729

Do you know of a great paper that uses QWF from Tocris? Please let us know.

Reviews for QWF

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Protocols for QWF

The following protocol features additional information for the use of QWF (Cat. No. 6642).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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