Pricing Availability   Qty
Description: MRGPRX2 antagonist; also NK1 receptor antagonist
Purity: ≥90% (HPLC)
Citations (2)
Protocols (1)

Biological Activity for QWF

QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

For more information about how QWF may be used, see our protocol:

3D Culture of Lung Alveolar Cells

Technical Data for QWF

M. Wt 697.78
Formula C38H43N5O8
Sequence QWF

(Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl)

Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 126088-82-2
PubChem ID 336446954
Smiles CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for QWF

Solubility Soluble to 10 mg/ml in DMSO

Product Datasheets for QWF

Certificate of Analysis / Product Datasheet
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References for QWF

References are publications that support the biological activity of the product.

Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID: 1375965

Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID: 27734033

If you know of a relevant reference for QWF, please let us know.

View Related Products by Product Action

View all Mas-Related G Protein-Coupled Receptors Antagonists

Keywords: QWF, QWF supplier, substance, P, antagonist, antagonism, NK1R, neurokinin, 1, mas-related, GPCR, X2, MRGPRX2, mast, cell, degranulation, SP, MRGX2, Mas-related, G, Protein-Coupled, Receptors, NK1, Receptor, 6642, Tocris Bioscience

2 Citations for QWF

Citations are publications that use Tocris products. Selected citations for QWF include:

Caroline L et al (2020) Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity 53 1063-1077.e7 PMID: 33098765

Song and Shim et al (2021) Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice Biomol Ther (Seoul) 30(1) 38 PMID: 34263729

Do you know of a great paper that uses QWF from Tocris? Please let us know.

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Protocols for QWF

The following protocol features additional information for the use of QWF (Cat. No. 6642).