QWF

Pricing Availability   Qty
Cat.No. 6642 - QWF | Boc-Gln-D-Trp(Formyl)-Phe-OBzl | CAS No. 126088-82-2
Description: MRGPRX2 antagonist; also NK1 receptor antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

Technical Data

M. Wt 697.78
Formula C38H43N5O8
Sequence QWF

(Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp (Formyl), Phe-3 = Phe-OBzl)

Storage Store at -20°C
CAS Number 126088-82-2
PubChem ID 336446954
InChI Key ZFZOHFAASQHWER-NCRUWMDKNA-N
Smiles CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mg/ml in DMSO

References

References are publications that support the biological activity of the product.

Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID: 1375965

Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID: 27734033


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Keywords: QWF, QWF supplier, substance, P, antagonist, antagonism, NK1R, neurokinin, 1, mas-related, GPCR, X2, MRGPRX2, mast, cell, degranulation, SP, MRGX2, Mas-related, G, Protein-Coupled, Receptors, NK1, Receptor, 6642, Tocris Bioscience

Citations for QWF

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Literature in this Area

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