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Submit ReviewQWF
Description: MRGPRX2 antagonist; also NK1 receptor antagonist
Purity: ≥90% (HPLC)
Biological Activity for QWF
QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
For more information about how QWF may be used, see our protocol:
3D Culture of Lung Alveolar CellsTechnical Data for QWF
| M. Wt | 697.78 |
| Formula | C38H43N5O8 |
| Sequence |
QWF (Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl) |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 126088-82-2 |
| PubChem ID | 336446954 |
| InChI Key | ZFZOHFAASQHWER-NCRUWMDKNA-N |
| Smiles | CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for QWF
| Solubility | Soluble to 10 mg/ml in DMSO |
Product Datasheets for QWF
References for QWF
References are publications that support the biological activity of the product.
Hagiwara et al (1992) Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 35 2015 PMID: 1375965
Azimi et al (2016) Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 1 e89362 PMID: 27734033
If you know of a relevant reference for QWF, please let us know.
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Keywords: QWF, QWF supplier, substance, P, antagonist, antagonism, NK1R, neurokinin, 1, mas-related, GPCR, X2, MRGPRX2, mast, cell, degranulation, SP, MRGX2, Mas-related, G, Protein-Coupled, Receptors, NK1, Receptor, 6642, Tocris Bioscience
2 Citations for QWF
Citations are publications that use Tocris products. Selected citations for QWF include:
Caroline L et al (2020) Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity 53 1063-1077.e7 PMID: 33098765
Song and Shim et al (2021) Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice Biomol Ther (Seoul) 30(1) 38 PMID: 34263729
Do you know of a great paper that uses QWF from Tocris? Please let us know.
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