ML 382

Pricing Availability   Qty
Description: MRGPRX1 positive allosteric modulator
Chemical Name: 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity for ML 382

ML 382 is a selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.

Technical Data for ML 382

M. Wt 360.43
Formula C18H20N2O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1646499-97-9
PubChem ID 71598556
Smiles O=C(NC1=C(OCC)C=CC=C1)C2=C(NS(C3CC3)(=O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 382

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.04 100
ethanol 7.21 20 with gentle warming

Preparing Stock Solutions for ML 382

The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for ML 382

References are publications that support the biological activity of the product.

Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID: 25209672

If you know of a relevant reference for ML 382, please let us know.

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Citations for ML 382

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