ML 382

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Cat.No. 5738 - ML 382 | C18H20N2O4S | CAS No. 1646499-97-9
Description: MrgX1 (SNSR4) positive allosteric modulator
Chemical Name: 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective MrgX1 (SNSR4) positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MrgX1 by 7-fold.

Technical Data

M. Wt 360.43
Formula C18H20N2O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1646499-97-9
PubChem ID 71598556
InChI Key RCSLEKLNDJJJLF-UHFFFAOYSA-N
Smiles O=C(NC1=C(OCC)C=CC=C1)C2=C(NS(C3CC3)(=O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100
ethanol 7.21 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID: 25209672


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Citations for ML 382

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Literature in this Area

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