You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for ML 382
ML 382 is a selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.
Technical Data for ML 382
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 382
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||7.21||20 with gentle warming|
Preparing Stock Solutions for ML 382
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.87 mL||27.74 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References for ML 382
References are publications that support the biological activity of the product.
Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID: 25209672
If you know of a relevant reference for ML 382, please let us know.
View Related Products by Product Action
Keywords: ML 382, ML 382 supplier, ML382, VU0485891, MrgX1,, SNSR4, sensory, neuron-specific, receptors, positive, allosteric, modulators, selective, PAM, Mas-related, G, Protein-Coupled, Receptors, 5738, Tocris Bioscience
Citations for ML 382
Citations are publications that use Tocris products.
Currently there are no citations for ML 382. Do you know of a great paper that uses ML 382 from Tocris? Please let us know.
Reviews for ML 382
There are currently no reviews for this product. Be the first to review ML 382 and earn rewards!
Have you used ML 382?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image