Selective MrgX1 (SNSR4) positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MrgX1 by 7-fold.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||7.21||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.87 mL||27.74 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References are publications that support the biological activity of the product.
Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID: 25209672
If you know of a relevant reference for ML 382, please let us know.
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Keywords: ML 382, ML 382 supplier, ML382, VU0485891, MrgX1,, SNSR4, sensory, neuron-specific, receptors, positive, allosteric, modulators, selective, Sensory, Neuron-Specific, Receptors, 5738, Tocris Bioscience
Citations for ML 382
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Literature in this Area
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