BAM (8-22)
Biological Activity
Endogenous peptide fragment that is a selective agonist for the sensory neuron specific receptor (EC50 values are 28 and 14 nM for SNSR3 and SNSR4 respectively); first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors.
Technical Data
| M. Wt | 1971.22 |
| Formula | C91H127N25O23S |
| Sequence | VGRPEWWMDYQKRYG |
| Storage | Desiccate at -20°C |
| CAS Number | 412961-36-5 |
| PubChem ID | 16158367 |
| InChI Key | GOEYECACIBFJGZ-NPAGUKBMSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1971.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.51 mL | 2.54 mL | 5.07 mL |
| 5 mM | 0.1 mL | 0.51 mL | 1.01 mL |
| 10 mM | 0.05 mL | 0.25 mL | 0.51 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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References
References are publications that support the products' biological activity.
Chen and Ikeda (2004) Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 24 5044 PMID: 15163697
Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303
If you know of a relevant reference for BAM (8-22), please let us know.
View Related Products by Target
Keywords: Selective agonists sensory neuron-specific receptors SNSR Sensory Neuron-Specific Receptor Peptide
2 Citations for BAM (8-22)
Citations are publications that use Tocris products. Selected citations for BAM (8-22) include:
Hin et al (2014) Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem 22 5831 PMID: 25288495
Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093 PMID: 23554490
Do you know of a great paper that uses BAM (8-22) from Tocris? If so please let us know.