Home / Pharmacology / 7-TM Receptors / Peptide Receptors / Sensory Neuron-Specific Receptors / Sensory Neuron-Specific Receptor Agonists / BAM (8-22)

BAM (8-22)

Cat. No. 1763 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability Delivery Time Qty
Cat.No. 1763 - BAM (8-22) | Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly | CAS No. 412961-36-5
Description: Selective agonist for the sensory neuron specific receptor (SNSR)
Datasheet
Citations (2)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous peptide fragment that is a selective agonist for the sensory neuron specific receptor (EC50 values are 28 and 14 nM for SNSR3 and SNSR4 respectively); first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors.

Technical Data

M. Wt 1971.22
Formula C91H127N25O23S
Sequence VGRPEWWMDYQKRYG
Storage Desiccate at -20°C
CAS Number 412961-36-5
PubChem ID 16158367
InChI Key GOEYECACIBFJGZ-NPAGUKBMSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1971.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.51 mL 2.54 mL 5.07 mL
5 mM 0.1 mL 0.51 mL 1.01 mL
10 mM 0.05 mL 0.25 mL 0.51 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the biological activity of the product.

Chen and Ikeda (2004) Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 24 5044 PMID: 15163697

Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634

Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303

If you know of a relevant reference for BAM (8-22), please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sensory Neuron-Specific Receptor Agonists

Keywords: BAM (8-22), BAM (8-22) supplier, Selective, agonists, sensory, neuron-specific, receptors, SNSR, Sensory, Neuron-Specific, Receptors, 1763, Tocris Bioscience

2 Citations for BAM (8-22)

Citations are publications that use Tocris products. Selected citations for BAM (8-22) include:

Hin et al (2014) Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem 22 5831 PMID: 25288495

Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093 PMID: 23554490

Do you know of a great paper that uses BAM (8-22) from Tocris? Please let us know.

Reviews for BAM (8-22)

There are currently no reviews for this product. Be the first to review BAM (8-22) and earn rewards!

Have you used BAM (8-22)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling