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Endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM); first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Chen and Ikeda (2004) Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 24 5044 PMID: 15163697
Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634
Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev 66 570 PMID: 24867890
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Keywords: BAM (8-22), BAM (8-22) supplier, Selective, agonists, sensory, neuron-specific, receptors, SNSR, MRGPRX1, mas-related, g, protein, coupled, agonism, potent, Mas-related, G, Protein-Coupled, Receptors, 1763, Tocris Bioscience
4 Citations for BAM (8-22)
Citations are publications that use Tocris products. Selected citations for BAM (8-22) include:
Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093 PMID: 23554490
Hin et al (2014) Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem 22 5831 PMID: 25288495
Honda et al (2019) Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with CP-induced cystitis. Cent European J Urol 72 142 PMID: 31482020
Sanjel et al (2019) BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci Rep 9 10888 PMID: 31350433
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.