PAMP-20 (human)

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Description: MRGPRX2 agonist; also non-competitive nAChR antagonist
Purity: ≥95% (HPLC)

Biological Activity for PAMP-20 (human)

PAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

Technical Data for PAMP-20 (human)

M. Wt 2460.87
Formula C112H178N36O27

(Modifications: Arg-20 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 150238-87-2
PubChem ID 71311703
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PAMP-20 (human)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for PAMP-20 (human)

Certificate of Analysis / Product Datasheet
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References for PAMP-20 (human)

References are publications that support the biological activity of the product.

Mahata et al (1998) Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension 32 907 PMID: 9822452

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun, 330 1146 PMID: 15823563

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Keywords: PAMP-20 (human), PAMP-20 (human) supplier, PAMP, n-terminal, 1-20, human, proadrenomedullin, ProAM, N20, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, Mas-related, G, Protein-Coupled, Receptors, Nicotinic, (Non-selective), 6552, Tocris Bioscience

Citations for PAMP-20 (human)

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