PAMP-12 (human, porcine)

Pricing Availability   Qty
Cat.No. 6551 - PAMP-12 (human, porcine) | Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 | CAS No. 196305-05-2
Description: Potent MRGPRX2 agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.

Technical Data

M. Wt 1618.95
Formula C77H119N25O14
Sequence FRKKWNKWALSR

(Modifications: Arg-12 = C-terminal amide)

Storage Store at -20°C
CAS Number 196305-05-2
PubChem ID 16137959
InChI Key DNUWKYBPCFUDDK-DYQOJKGJSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563

Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109


If you know of a relevant reference for PAMP-12 (human, porcine), please let us know.

View Related Products by Target

View Related Products by Product Action

View all Orphan 7-TM Receptor Agonists

Keywords: PAMP-12 (human, porcine), PAMP-12 (human, porcine) supplier, PAMP-12, human, porcine, proadrenomedullin, ProAM, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, potent, Orphan, 7-TM, Receptors, 6551, Tocris Bioscience

Citations for PAMP-12 (human, porcine)

Citations are publications that use Tocris products.

Currently there are no citations for PAMP-12 (human, porcine). Do you know of a great paper that uses PAMP-12 (human, porcine) from Tocris? Please let us know.

Reviews for PAMP-12 (human, porcine)

There are currently no reviews for this product. Be the first to review PAMP-12 (human, porcine) and earn rewards!

Have you used PAMP-12 (human, porcine)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling