PAMP-12 (human, porcine)

Pricing Availability   Qty
Description: Potent MRGPRX2 agonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for PAMP-12 (human, porcine)

PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.

Technical Data for PAMP-12 (human, porcine)

M. Wt 1618.95
Formula C77H119N25O14
Sequence FRKKWNKWALSR

(Modification: Arg-12 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 196305-05-2
PubChem ID 16137959
InChI Key DNUWKYBPCFUDDK-DYQOJKGJSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PAMP-12 (human, porcine)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for PAMP-12 (human, porcine)

Certificate of Analysis / Product Datasheet
Select another batch:

References for PAMP-12 (human, porcine)

References are publications that support the biological activity of the product.

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563

Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109


If you know of a relevant reference for PAMP-12 (human, porcine), please let us know.

View Related Products by Product Action

View all Mas-Related G Protein-Coupled Receptors Agonists

Keywords: PAMP-12 (human, porcine), PAMP-12 (human, porcine) supplier, PAMP-12, human, porcine, proadrenomedullin, ProAM, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, potent, Mas-related, G, Protein-Coupled, Receptors, 6551, Tocris Bioscience

Citations for PAMP-12 (human, porcine)

Citations are publications that use Tocris products.

Currently there are no citations for PAMP-12 (human, porcine). Do you know of a great paper that uses PAMP-12 (human, porcine) from Tocris? Please let us know.

Reviews for PAMP-12 (human, porcine)

There are currently no reviews for this product. Be the first to review PAMP-12 (human, porcine) and earn rewards!

Have you used PAMP-12 (human, porcine)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.