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Submit ReviewPAMP-12 (human, porcine)
Description: Potent MRGPRX2 agonist
Purity: ≥95% (HPLC)
Biological Activity for PAMP-12 (human, porcine)
PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.
Technical Data for PAMP-12 (human, porcine)
| M. Wt | 1618.95 |
| Formula | C77H119N25O14 |
| Sequence |
FRKKWNKWALSR (Modification: Arg-12 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 196305-05-2 |
| PubChem ID | 16137959 |
| InChI Key | DNUWKYBPCFUDDK-DYQOJKGJSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PAMP-12 (human, porcine)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for PAMP-12 (human, porcine)
References for PAMP-12 (human, porcine)
References are publications that support the biological activity of the product.
Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563
Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109
If you know of a relevant reference for PAMP-12 (human, porcine), please let us know.
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Keywords: PAMP-12 (human, porcine), PAMP-12 (human, porcine) supplier, PAMP-12, human, porcine, proadrenomedullin, ProAM, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, potent, Mas-related, G, Protein-Coupled, Receptors, 6551, Tocris Bioscience
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