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Biological Activity for PAMP-12 (human, porcine)
PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.
Technical Data for PAMP-12 (human, porcine)
(Modification: Arg-12 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PAMP-12 (human, porcine)
|Solubility||Soluble to 1 mg/ml in water|
Product Datasheets for PAMP-12 (human, porcine)
References for PAMP-12 (human, porcine)
References are publications that support the biological activity of the product.
Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563
Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109
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Keywords: PAMP-12 (human, porcine), PAMP-12 (human, porcine) supplier, PAMP-12, human, porcine, proadrenomedullin, ProAM, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, potent, Mas-related, G, Protein-Coupled, Receptors, 6551, Tocris Bioscience
Citations for PAMP-12 (human, porcine)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.