PAMP-12 (human, porcine)

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Description: Potent MRGPRX2 agonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for PAMP-12 (human, porcine)

PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.

Technical Data for PAMP-12 (human, porcine)

M. Wt 1618.95
Formula C77H119N25O14
Sequence FRKKWNKWALSR

(Modification: Arg-12 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 196305-05-2
PubChem ID 16137959
InChI Key DNUWKYBPCFUDDK-DYQOJKGJSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PAMP-12 (human, porcine)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for PAMP-12 (human, porcine)

Certificate of Analysis / Product Datasheet
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References for PAMP-12 (human, porcine)

References are publications that support the biological activity of the product.

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563

Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109


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Citations for PAMP-12 (human, porcine)

Citations are publications that use Tocris products.

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