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Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo. Also potent MRGPRX2 agonist.
(Modifications: Disulfide bridge between 2 - 13)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 0.70 mg/ml in water|
References are publications that support the biological activity of the product.
Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1 PMID: 11227737
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157
Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
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Keywords: Cortistatin 14, Cortistatin 14 supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, mas-related, g, protein-coupled, receptors, MRGPRX2, Mas-related, G, Protein-Coupled, 3374, Tocris Bioscience
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