Cortistatin 14

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Description: Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Cortistatin 14

Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Technical Data for Cortistatin 14

M. Wt 1721.03
Formula C81H113N19O19S2
Sequence PCKNFFWKTFSSCK

(Modifications: Disulfide bridge: 2-13)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 193829-96-8
PubChem ID 16133803
InChI Key DDRPLNQJNRBRNY-WYYADCIBSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cortistatin 14

Solubility Soluble to 0.70 mg/ml in water

Product Datasheets for Cortistatin 14

Certificate of Analysis / Product Datasheet
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References for Cortistatin 14

References are publications that support the biological activity of the product.

Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1 PMID: 11227737

Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157 PMID: 9125122

Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228 PMID: 11011067

Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890

Robas et al (2003) MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J.Biol.Chem. 278 44400 PMID: 12915402


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Keywords: Cortistatin 14, Cortistatin 14 supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, mas-related, g, protein-coupled, receptors, MRGPRX2, Mas-related, G, Protein-Coupled, 3374, Tocris Bioscience

Citations for Cortistatin 14

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Literature in this Area

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