Neuropeptide FF

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Description: Endogenous NPFF1 and NPFF2 agonist; also MRGPRA agonist
Purity: ≥95% (HPLC)

Biological Activity for Neuropeptide FF

Neuropeptide FF is an endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration. Also MRGPRA agonist.

Technical Data for Neuropeptide FF

M. Wt 1081.28
Formula C54H76N14O10

(Modifications: Phe-8 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 99566-27-5
PubChem ID 9854861
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Neuropeptide FF

Solubility Soluble to 0.50 mg/ml in water

Product Datasheets for Neuropeptide FF

Certificate of Analysis / Product Datasheet
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References for Neuropeptide FF

References are publications that support the biological activity of the product.

Cline et al (2007) Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides 41 433 PMID: 17936900

Gouarderes et al (2007) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[35S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599

Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890

If you know of a relevant reference for Neuropeptide FF, please let us know.

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Keywords: Neuropeptide FF, Neuropeptide FF supplier, Endogenous, NPFF1, NPFF2, agonists, Anti-opioids, NPFFR1, NPFFR2, Receptors, Neuropeptides, FF/AF, NeuropeptideFF, MRGPRA, mas-related, g, protein-coupled, agonism, Miscellaneous/Non-selective, Opioids, Neuropeptide, Mas-related, G, Protein-Coupled, 3137, Tocris Bioscience

Citations for Neuropeptide FF

Citations are publications that use Tocris products.

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