iNOS

Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. It displays high affinity for Ca2+/calmodulin.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
0787 Aminoguanidine hydrochloride
Irreversible iNOS inhibitor
0871 AMT hydrochloride
Potent, selective iNOS inhibitor
3969 AR-C 102222
Selective iNOS inhibitor
2866 BYK 191023 dihydrochloride
Potent and selective inhibitor of iNOS
0873 EIT hydrobromide
Selective iNOS inhibitor, acts arginine binding site
0951 2-Iminopiperidine hydrochloride
Selective iNOS inhibitor
0897 S-Isopropylisothiourea hydrobromide
iNOS inhibitor, acts at arginine binding site
0776 (S)-Methylisothiourea sulfate
Highly selective iNOS inhibitor
1139 L-NIL hydrochloride
Selective iNOS inhibitor
0546 L-NIO dihydrochloride
NOS inhibitor
1415 1400W dihydrochloride
Potent, highly selective iNOS inhibitor

Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. It displays high affinity for Ca2+/calmodulin, thus appears to be constitutively active. Tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH co-factors are required for catalytic activity.

iNOS gene expression is regulated by various pathways including NF-κB, IFN-γ (signaling through the JAK-STAT cascade) and HIF-1, which induce expression, and TGF-β and interleukins -4, -10 and -13, which inhibit expression. Post-translational regulation occurs by prevention of iNOS homodimerization by NAP110.

iNOS has roles in the innate immune system and displays antibacterial, antiviral and antifungal activity. The human gene encoding iNOS is localized to chromosome 17q11.2-q12.

Literature for iNOS

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iNOS Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human NOS2 NM_000625 P35228
Mouse Nos2 NM_010927 P29477
Rat Nos2 NM_012611 Q6XS76