NO Synthases
NO synthases utilize L-arginine and molecular oxygen to generate nitric oxide and L-citrulline. eNOS and nNOS are activated by calcium at concentrations > 100 nM whilst iNOS is constitutively active. All three isoforms exist as homodimers and require tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity. NO synthases have roles in neurotransmission, vasodilation and immune function through the actions of the product nitric oxide.
Nitric Oxide Biosynthesis Pathway
Moncada et al (1997) XIV. International Union of Pharmacology Nomenclature in Nitric Oxide Research. Pharmacol.Rev. 49 137.
Literature for NO Synthases
Tocris offers the following scientific literature for NO Synthases to showcase our products. We invite you to request* your copy today!
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Our Cancer Research Guide highlights over 750 products for cancer research.
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Our Pain guide highlights over 280 products for Pain research.
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Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression.
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