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NO synthases utilize L-arginine and molecular oxygen to generate nitric oxide and L-citrulline. eNOS and nNOS are activated by calcium at concentrations > 100 nM whilst iNOS is constitutively active. All three isoforms exist as homodimers and require tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity. NO synthases have roles in neurotransmission, vasodilation and immune function through the actions of the product nitric oxide.
Moncada et al (1997) XIV. International Union of Pharmacology Nomenclature in Nitric Oxide Research. Pharmacol.Rev. 49 137.
Tocris offers the following scientific literature for NO Synthases to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.