NO Synthases

NO synthases utilize L-arginine and molecular oxygen to generate nitric oxide and L-citrulline. eNOS and nNOS are activated by calcium at concentrations > 100 nM whilst iNOS is constitutively active. All three isoforms exist as homodimers and require tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity. NO synthases have roles in neurotransmission, vasodilation and immune function through the actions of the product nitric oxide.

Targets
Literature

NO Synthase Target Files

Nitric Oxide Biosynthesis Pathway

Pathway for Nitric Oxide Biosynthesis

Moncada et al (1997) XIV. International Union of Pharmacology Nomenclature in Nitric Oxide Research. Pharmacol.Rev. 49 137.

Literature for NO Synthases

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.