AMT hydrochloride

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Cat.No. 0871 - AMT hydrochloride | C5H10N2S.HCl | CAS No. 21463-31-0
Description: Potent, selective iNOS inhibitor
Chemical Name: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Citations (3)

Biological Activity

Potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

Technical Data

M. Wt 166.67
Formula C5H10N2S.HCl
Storage Desiccate at +4°C
CAS Number 21463-31-0
PubChem ID 2733501
Smiles NC1=NCCC(S1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 166.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6 mL 30 mL 60 mL
5 mM 1.2 mL 6 mL 12 mL
10 mM 0.6 mL 3 mL 6 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Liao et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 20 E1196 PMID: 16877524

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889

Yu et al (2005) Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 566 327 PMID: 15845578

If you know of a relevant reference for AMT hydrochloride, please let us know.

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Keywords: AMT hydrochloride, supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, iNOS, Tocris Bioscience

3 Citations for AMT hydrochloride

Citations are publications that use Tocris products. Selected citations for AMT hydrochloride include:

Lee et al (2016) Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. PLoS One 24 67 PMID: 26759704

Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397 PMID: 10742295

Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161

Do you know of a great paper that uses AMT hydrochloride from Tocris? If so please let us know.

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