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Biological Activity for AMT hydrochloride
AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).
Technical Data for AMT hydrochloride
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AMT hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AMT hydrochloride
The following data is based on the product molecular weight 166.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||60 mL||299.99 mL||599.99 mL|
|0.5 mM||12 mL||60 mL||120 mL|
|1 mM||6 mL||30 mL||60 mL|
|5 mM||1.2 mL||6 mL||12 mL|
Product Datasheets for AMT hydrochloride
References for AMT hydrochloride
References are publications that support the biological activity of the product.
Liao et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 20 E1196 PMID: 16877524
Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889
Yu et al (2005) Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 566 327 PMID: 15845578
If you know of a relevant reference for AMT hydrochloride, please let us know.
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Keywords: AMT hydrochloride, AMT hydrochloride supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0871, Tocris Bioscience
5 Citations for AMT hydrochloride
Citations are publications that use Tocris products. Selected citations for AMT hydrochloride include:
Wong et al (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta. Br J Pharmacol 174 718 PMID: 28138957
Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397 PMID: 10742295
Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161
Lee et al (2016) Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. PLoS One 24 67 PMID: 26759704
Lee et al (2018) Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways. J Ginseng Res 42 476 PMID: 30337808
Do you know of a great paper that uses AMT hydrochloride from Tocris? Please let us know.
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Literature in this Area
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