AMT hydrochloride

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Cat.No. 0871 - AMT hydrochloride | C5H10N2S.HCl | CAS No. 21463-31-0
Description: Potent, selective iNOS inhibitor
Chemical Name: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Datasheet
Citations (5)
Reviews
Literature (3)

Biological Activity

Potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

Technical Data

M. Wt 166.67
Formula C5H10N2S.HCl
Storage Desiccate at +4°C
CAS Number 21463-31-0
PubChem ID 2733501
InChI Key HVJCRMIQAMEJNM-UHFFFAOYSA-N
Smiles NC1=NCCC(S1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10

Preparing Stock Solutions

The following data is based on the product molecular weight 166.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 60 mL 299.99 mL 599.99 mL
0.5 mM 12 mL 60 mL 120 mL
1 mM 6 mL 30 mL 60 mL
5 mM 1.2 mL 6 mL 12 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Liao et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 20 E1196 PMID: 16877524

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889

Yu et al (2005) Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 566 327 PMID: 15845578


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Keywords: AMT hydrochloride, AMT hydrochloride supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0871, Tocris Bioscience

5 Citations for AMT hydrochloride

Citations are publications that use Tocris products. Selected citations for AMT hydrochloride include:

Wong et al (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta. Br J Pharmacol 174 718 PMID: 28138957

Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397 PMID: 10742295

Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161

Lee et al (2018) Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways. J Ginseng Res 42 476 PMID: 30337808


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Literature in this Area

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