L-NIO dihydrochloride

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Cat.No. 0546 - L-NIO dihydrochloride | C7H15N3O2.2HCl | CAS No. 159190-44-0
Description: NOS inhibitor
Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride
Datasheet
Citations (8)
Reviews
Literature (1)

Biological Activity

Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.

Technical Data

M. Wt 246.13
Formula C7H15N3O2.2HCl
Storage Desiccate at -20°C
CAS Number 159190-44-0
PubChem ID 2733507
InChI Key RYCMAAFECCXGHI-ILKKLZGPSA-N
Smiles N[C@H](C(O)=O)CCCNC(C)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 246.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.31 mL 40.63 mL
5 mM 0.81 mL 4.06 mL 8.13 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137 PMID: 9228663

Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159 PMID: 1281719

Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746 PMID: 1706208


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Keywords: L-NIO dihydrochloride, L-NIO dihydrochloride supplier, Potent, eNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Endothelial, Synthase, NO, Synthases, iNOS, nNOS, 0546, Tocris Bioscience

8 Citations for L-NIO dihydrochloride

Citations are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:

Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats. Endocrinology 10 e0140762 PMID: 26485682

Bergeron et al (2015) Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. PLoS Negl Trop Dis 156 638 PMID: 25456068

Bender and Abdel-Rahman (2010) Differential central NOS-NO signaling underlies clon. exacerbation of ethanol-evoked behavioral impairment. Alcohol Clin Exp Res 34 555 PMID: 20028349

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451


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