L-NIO dihydrochloride

Pricing Availability   Qty
Description: NOS inhibitor
Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride
Citations (8)
Literature (1)

Biological Activity for L-NIO dihydrochloride

L-NIO dihydrochloride is an Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.

Technical Data for L-NIO dihydrochloride

M. Wt 246.13
Formula C7H15N3O2.2HCl
Storage Desiccate at -20°C
CAS Number 159190-44-0
PubChem ID 2733507
Smiles N[C@H](C(O)=O)CCCNC(C)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-NIO dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 24.61 100

Preparing Stock Solutions for L-NIO dihydrochloride

The following data is based on the product molecular weight 246.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.31 mL 40.63 mL
5 mM 0.81 mL 4.06 mL 8.13 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for L-NIO dihydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for L-NIO dihydrochloride

References are publications that support the biological activity of the product.

Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137 PMID: 9228663

Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159 PMID: 1281719

Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746 PMID: 1706208

If you know of a relevant reference for L-NIO dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all eNOS Inhibitors

Keywords: L-NIO dihydrochloride, L-NIO dihydrochloride supplier, Potent, eNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Endothelial, Synthase, NO, Synthases, iNOS, nNOS, 0546, Tocris Bioscience

8 Citations for L-NIO dihydrochloride

Citations are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:

Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924

Penumarti and Abdel-Rahman (2014) Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats. J Pharmacol Exp Ther 351 44 PMID: 25100751

Bender and Abdel-Rahman (2010) Differential central NOS-NO signaling underlies clon. exacerbation of ethanol-evoked behavioral impairment. Alcohol Clin Exp Res 34 555 PMID: 20028349

Chang et al (2002) Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat. Br J Pharmacol 136 43313 PMID: 11976262

Do you know of a great paper that uses L-NIO dihydrochloride from Tocris? Please let us know.

Reviews for L-NIO dihydrochloride

There are currently no reviews for this product. Be the first to review L-NIO dihydrochloride and earn rewards!

Have you used L-NIO dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis