L-NIO dihydrochloride

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Description: NOS inhibitor
Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride
Datasheet
Citations (8)
Reviews

Biological Activity for L-NIO dihydrochloride

L-NIO dihydrochloride is an Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.

Technical Data for L-NIO dihydrochloride

M. Wt 246.13
Formula C7H15N3O2.2HCl
Storage Desiccate at -20°C
CAS Number 159190-44-0
PubChem ID 2733507
InChI Key RYCMAAFECCXGHI-ILKKLZGPSA-N
Smiles N[C@H](C(O)=O)CCCNC(C)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-NIO dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.61 100

Preparing Stock Solutions for L-NIO dihydrochloride

The following data is based on the product molecular weight 246.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.31 mL 40.63 mL
5 mM 0.81 mL 4.06 mL 8.13 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets for L-NIO dihydrochloride

Certificate of Analysis / Product Datasheet
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References for L-NIO dihydrochloride

References are publications that support the biological activity of the product.

Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137 PMID: 9228663

Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159 PMID: 1281719

Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746 PMID: 1706208


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Keywords: L-NIO dihydrochloride, L-NIO dihydrochloride supplier, Potent, eNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Endothelial, Synthase, NO, Synthases, iNOS, nNOS, 0546, Tocris Bioscience

8 Citations for L-NIO dihydrochloride

Citations are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451

Wu et al (2013) Vasorelaxin: a novel arterial smooth muscle-relaxing eicosapeptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri). PLoS One 8 e55739 PMID: 23405205

Chang et al (2002) Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat. Br J Pharmacol 136 43313 PMID: 11976262

Penumarti and Abdel-Rahman (2014) Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats. J Pharmacol Exp Ther 351 44 PMID: 25100751


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