Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 246.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.06 mL||20.31 mL||40.63 mL|
|5 mM||0.81 mL||4.06 mL||8.13 mL|
|10 mM||0.41 mL||2.03 mL||4.06 mL|
|50 mM||0.08 mL||0.41 mL||0.81 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137 PMID: 9228663
Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159 PMID: 1281719
Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746 PMID: 1706208
If you know of a relevant reference for L-NIO dihydrochloride, please let us know.
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Keywords: Potent eNOS inhibitors inhibits Nitric Oxide Signaling Signalling Endothelial Synthase NO Synthases eNOS
5 Citations for L-NIO dihydrochloride
Citations are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:
Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Insulin-Resistant Rats. Endocrinology 10 e0140762 PMID: 26485682
Bergeron et al (2015) Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. PLoS Negl Trop Dis 156 638 PMID: 25456068
Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451
Wu et al (2013) Vasorelaxin: a novel arterial smooth muscle-relaxing eicosapeptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri). PLoS One 8 e55739 PMID: 23405205
Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924
Do you know of a great paper that uses L-NIO dihydrochloride from Tocris? If so please let us know.