1400W dihydrochloride

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Cat.No. 1415 - 1400W dihydrochloride | C10H15N3.2HCl | CAS No. 214358-33-5
Description: Potent, highly selective iNOS inhibitor
Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews (1)
Literature

Biological Activity

Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo.

Technical Data

M. Wt 250.17
Formula C10H15N3.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 214358-33-5
PubChem ID 2733515
InChI Key WDJHSQZCZGPGAA-UHFFFAOYSA-N
Smiles Cl.Cl.CC(=N)NCC1=CC=CC(CN)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 250.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 19.99 mL 39.97 mL
5 mM 0.8 mL 4 mL 7.99 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Garvey et al (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J.Biol.Chem. 272 4959 PMID: 9030556

Parmentier et al (1999) Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br.J.Pharmacol. 127 546 PMID: 10385257

Thomsen et al (1997) Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 57 3300 PMID: 9242464


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Keywords: 1400W dihydrochloride, 1400W dihydrochloride supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 1415, Tocris Bioscience

7 Citations for 1400W dihydrochloride

Citations are publications that use Tocris products. Selected citations for 1400W dihydrochloride include:

Kuen et al (2017) Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model. PLoS One 12 e0182039 PMID: 28750018

Al-Shalmani et al (2011) Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. Br J Pharmacol 162 1485 PMID: 21375526

Clark et al (2015) Selective activation of microglia facilitates synaptic strength. RNA 35 4552 PMID: 25788673

Gresa-Arribas et al (2012) Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS One 7 e45227 PMID: 23028862

Ashrafpour et al (2004) Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature. Am J Physiol Heart Circ Physiol 286 H946 PMID: 14644765

Tsuda et al (2009) Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J Cell Mol Med 13 3251 PMID: 19298529

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451


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Reviews for 1400W dihydrochloride

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iNOS inhibitor
By Anonymous on 07/28/2018
Assay Type: Ex Vivo
Species: Mouse

Used as iNOS inhibitor for organ bath experiments with rat and mouse aorta

Good solubility and stability


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