GPR35

GPR35 is a Class A, rhodopsin-like G protein-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancreas (human GPR35).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0223 Kynurenic acid
Endogenous GPR35 ligand
3694 Kynurenic acid sodium salt
Sodium salt of kynurenic acid (Cat. No. 0223)
4112 Niflumic acid
Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
0593 NPPB
Putative GPR35 agonist
4298 Pamoic acid disodium salt
GPR35 agonist
0630 Rosmarinic acid
GPR35 agonist; anti-inflammatory, cytostatic and antiviral
4879 TC-G 1001
GPR35 agonist; more potent than zaprinast (Cat. No. 0947)
4244 TCS 3035
GPR35 agonist
4457 YE 120
GPR35 agonist
0947 Zaprinast
GPR35 agonist

Antagonists

Cat No Product Name / Activity
4293 CID 2745687
GPR35 antagonist
4172 ML 145
GPR35 antagonist

Related Targets

    GPR35 is a Class A, rhodopsin-like G protein-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancreas (human GPR35). Despite being first identified in 1998, the receptor is relatively poorly characterized and until recently was regarded as an orphan receptor. More recent work has identified kynurenic acid and lysophosphatidic acid as potential endogenous ligands for GPR35, and has also demonstrated that GPR35 functions as a receptor for T3 and reverse T3 thyroid hormones, rosmarinic acid, and 3-nitrotyrosine.

    Small nucleotide polymorphisms (SNPs) within GPR35 have been linked to cardiovascular disease, and GPR35 signaling is also thought to be involved in inflammation, nociception, and glucose metabolism. In addition. GPR35 has been reported as a potential oncogene in gastric cancer, and its tyrosine metabolite binding capability identifies GPR35 as a potential target for diseases associated with abnormal tyrosine metabolism.

    Literature for GPR35

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling

    GPR35 Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human GPR35 NM_001195381 Q9HC97
    Mouse Gpr35 NM_022320 Q9ES90
    Rat Gpr35 NM_001037359 Q33BM1