Kynurenic acid sodium salt

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Description: Sodium salt of kynurenic acid (Cat. No. 0223)
Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity for Kynurenic acid sodium salt

Kynurenic acid sodium salt is a sodium salt of kynurenic acid (Cat. No. 0223), a broad spectrum EAA antagonist.

Compound Libraries for Kynurenic acid sodium salt

Kynurenic acid sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Kynurenic acid sodium salt

M. Wt 211.15
Formula C10H6NNaO3
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2439-02-3
PubChem ID 52974250
InChI Key RCAZGXKUQDXSSK-UHFFFAOYSA-M
Smiles [Na+].OC1=CC(=NC2=CC=CC=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kynurenic acid sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.11 100
DMSO 10.56 50

Preparing Stock Solutions for Kynurenic acid sodium salt

The following data is based on the product molecular weight 211.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.74 mL 23.68 mL 47.36 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.74 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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Product Datasheets for Kynurenic acid sodium salt

Certificate of Analysis / Product Datasheet
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References for Kynurenic acid sodium salt

References are publications that support the biological activity of the product.

Perkins and Stone (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 184 PMID: 6215086

Pittaluga et al (1997) The 'kynurenate test', a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 283 82 PMID: 9336311

Wang et al (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 281 22021 PMID: 16754668

Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Progr.Neurobiol. 30 333 PMID: 2830636


If you know of a relevant reference for Kynurenic acid sodium salt, please let us know.

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Keywords: Kynurenic acid sodium salt, Kynurenic acid sodium salt supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, GPR35, 3694, Tocris Bioscience

2 Citations for Kynurenic acid sodium salt

Citations are publications that use Tocris products. Selected citations for Kynurenic acid sodium salt include:

Stefano et al (2022) Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility. Front Neurosci 16 961042 PMID: 35983226

Ruilong et al (2021) Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb. J Neurosci 41 3610-3621 PMID: 33687961


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Literature in this Area

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