CID 2745687

Pricing Availability   Qty
Description: GPR35 antagonist
Chemical Name: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for CID 2745687

CID 2745687 is a competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.

Compound Libraries for CID 2745687

CID 2745687 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CID 2745687

M. Wt 395.43
Formula C17H19F2N5O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 264233-05-8
PubChem ID 9581011
Smiles FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CID 2745687

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.54 100
ethanol 3.95 10

Preparing Stock Solutions for CID 2745687

The following data is based on the product molecular weight 395.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets for CID 2745687

Certificate of Analysis / Product Datasheet
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References for CID 2745687

References are publications that support the biological activity of the product.

Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560 PMID: 20826425

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846

If you know of a relevant reference for CID 2745687, please let us know.

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Keywords: CID 2745687, CID 2745687 supplier, CID2745687, orphan, receptors, antagonists, GPR35, antagonist, 4293, Tocris Bioscience

1 Citation for CID 2745687

Citations are publications that use Tocris products. Selected citations for CID 2745687 include:

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792

Do you know of a great paper that uses CID 2745687 from Tocris? Please let us know.

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