CID 2745687

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Cat.No. 4293 - CID 2745687 | C17H19F2N5O2S | CAS No. 264233-05-8
Description: GPR35 antagonist
Chemical Name: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid (Cat. No. 4298).

Compound Libraries

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Technical Data

M. Wt 395.43
Formula C17H19F2N5O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 264233-05-8
PubChem ID 9581011
InChI Key CYNLZIBKERMMOA-AWQFTUOYSA-N
Smiles FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.54 100
ethanol 3.95 10

Preparing Stock Solutions

The following data is based on the product molecular weight 395.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560 PMID: 20826425

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846


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Keywords: CID 2745687, CID 2745687 supplier, CID2745687, orphan, receptors, antagonists, GPR35, antagonist, 4293, Tocris Bioscience

1 Citation for CID 2745687

Citations are publications that use Tocris products. Selected citations for CID 2745687 include:

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792


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