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Biological Activity for TC-G 1001
TC-G 1001 is a GPR35 agonist (pEC50 values are 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast (Cat. No. 0947).
Technical Data for TC-G 1001
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-G 1001
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC-G 1001
The following data is based on the product molecular weight 342.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||29.21 mL||146.05 mL||292.11 mL|
|0.5 mM||5.84 mL||29.21 mL||58.42 mL|
|1 mM||2.92 mL||14.61 mL||29.21 mL|
|5 mM||0.58 mL||2.92 mL||5.84 mL|
References for TC-G 1001
References are publications that support the biological activity of the product.
Neetoo-Isseljee et al (2013) High-throughput identification and characterization of novel, species-selective GPR35 agonists. J.Pharmacol.Exp.Ther. 344 568 PMID: 23262279
If you know of a relevant reference for TC-G 1001, please let us know.
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Keywords: TC-G 1001, TC-G 1001 supplier, TC-G1001, GPR35, G, protein, coupled, receptor, 35, agonists, selective, 4879, Tocris Bioscience
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