TC-G 1001

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Description: GPR35 agonist; more potent than zaprinast (Cat. No. 0947)
Chemical Name: 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity for TC-G 1001

TC-G 1001 is a GPR35 agonist (pEC50 values are 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast (Cat. No. 0947).

Technical Data for TC-G 1001

M. Wt 342.34
Formula C17H11FN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 494191-73-0
PubChem ID 5766343
Smiles O=C1N=C(NC3=CC=CC=C3F)S/C1=C\C2=CC=C(C(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-G 1001

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.42 10

Preparing Stock Solutions for TC-G 1001

The following data is based on the product molecular weight 342.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.21 mL 146.05 mL 292.11 mL
0.5 mM 5.84 mL 29.21 mL 58.42 mL
1 mM 2.92 mL 14.61 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL

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References for TC-G 1001

References are publications that support the biological activity of the product.

Neetoo-Isseljee et al (2013) High-throughput identification and characterization of novel, species-selective GPR35 agonists. J.Pharmacol.Exp.Ther. 344 568 PMID: 23262279

If you know of a relevant reference for TC-G 1001, please let us know.

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Keywords: TC-G 1001, TC-G 1001 supplier, TC-G1001, GPR35, G, protein, coupled, receptor, 35, agonists, selective, 4879, Tocris Bioscience

Citations for TC-G 1001

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