TC-G 1001

Pricing Availability Delivery Time Qty
Cat.No. 4879 - TC-G 1001 | C17H11FN2O3S | CAS No. 494191-73-0
Description: GPR35 agonist; more potent than zaprinast (Cat. No. 0947)
Chemical Name: 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

GPR35 agonist (pEC50 values are 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast (Cat. No. 0947).

Technical Data

M. Wt 342.34
Formula C17H11FN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 494191-73-0
PubChem ID 5766343
InChI Key SYCKPHBALHXMIR-ZROIWOOFSA-N
Smiles O=C1N=C(NC3=CC=CC=C3F)S/C1=C\C2=CC=C(C(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.42 10

Preparing Stock Solutions

The following data is based on the product molecular weight 342.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.61 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Neetoo-Isseljee et al (2013) High-throughput identification and characterization of novel, species-selective GPR35 agonists. J.Pharmacol.Exp.Ther. 344 568 PMID: 23262279


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Keywords: TC-G 1001, supplier, TC-G1001, GPR35, G, protein, coupled, receptor, 35, agonists, selective, GPR35, GPR35, Tocris Bioscience

Citations for TC-G 1001

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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Pathways for TC-G 1001

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