ML 145

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Cat.No. 4172 - ML 145 | C24H22N2O5S2 | CAS No. 1164500-72-4
Description: GPR35 antagonist
Chemical Name: 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

Technical Data

M. Wt 482.57
Formula C24H22N2O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1164500-72-4
PubChem ID 2286812
InChI Key COFMYJWNXSFLKQ-QIROLCGISA-N
Smiles O=C(NC3=CC=C(C(O)=O)C(O)=C3)CCCN2C(/C(SC2=S)=C/C(C)=C/C1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 482.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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References

References are publications that support the biological activity of the product.

Heynen-Genel et al (2010) Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program NBK5070

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846


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Literature in this Area

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GPCR

GPCR Product Listing

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  • Frizzled Receptors
  • GPCR Signaling