ML 145

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Description: GPR35 antagonist
Chemical Name: 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity for ML 145

ML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

Technical Data for ML 145

M. Wt 482.57
Formula C24H22N2O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1164500-72-4
PubChem ID 2286812
Smiles O=C(NC3=CC=C(C(O)=O)C(O)=C3)CCCN2C(/C(SC2=S)=C/C(C)=C/C1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 145

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.26 100

Preparing Stock Solutions for ML 145

The following data is based on the product molecular weight 482.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets for ML 145

Certificate of Analysis / Product Datasheet
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References for ML 145

References are publications that support the biological activity of the product.

Heynen-Genel et al (2010) Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program NBK5070

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846

If you know of a relevant reference for ML 145, please let us know.

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Citations for ML 145

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