Kynurenic acid

Pricing Availability Delivery Time Qty
Cat.No. 0223 - Kynurenic acid | C10H7NO3 | CAS No. 492-27-3
Description: Broad spectrum EAA antagonist
Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Literature

Biological Activity

Broad spectrum EAA antagonist. Putative GPR35 ligand. Kynurenic acid sodium salt also available (Cat. No. 3694).

Compound Libraries

Kynurenic acid is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 189.17
Formula C10H7NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 492-27-3
PubChem ID 3845
InChI Key HCZHHEIFKROPDY-UHFFFAOYSA-N
Smiles OC(=O)C1=CC(O)=C2C=CC=CC2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 18.92 100
DMSO 9.46 50

Preparing Stock Solutions

The following data is based on the product molecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.29 mL 26.43 mL 52.86 mL
5 mM 1.06 mL 5.29 mL 10.57 mL
10 mM 0.53 mL 2.64 mL 5.29 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Perkins and Stone (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 184 PMID: 6215086

Pittaluga et al (1997) The 'kynurenate test,' a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 283 82 PMID: 9336311

Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Prog.Neurobiol. 30 333 PMID: 2830636

Wang et al (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 281 22021 PMID: 16754668


If you know of a relevant reference for Kynurenic acid, please let us know.

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Keywords: Kynurenic acid, supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, Ionotropic, Glutamate, Non-selective, mGlu, GPR35, Non-selective, Ionotropic, Glutamate, Tocris Bioscience

10 Citations for Kynurenic acid

Citations are publications that use Tocris products. Selected citations for Kynurenic acid include:

Wu et al (2013) Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis. J Pharmacol Exp Ther 346 146 PMID: 23667248

Chen et al (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. Neuron 33 8336 PMID: 23658173

Zhu et al (2011) Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell 147 1384 PMID: 22153080

Jones et al (2011) Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. Int J Neuropsychopharmacol 105 1984 PMID: 21325686

Shinoda et al (2011) Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. Eur J Neurosci 108 373 PMID: 21173225

Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. J Neurosci 63 482 PMID: 19709630

Perez-Leon et al (2006) Synaptic inputs to retinal ganglion cells that set the circadian clock. J Neurophysiol 24 1117 PMID: 16930437

Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. Proc Natl Acad Sci U S A 36 607 PMID: 26758848

Carver et al (2014) Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity. J Neurosci 34 14181 PMID: 25339733

Weston et al (2014) Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Front Mol Neurosci 7 1 PMID: 24574959


Do you know of a great paper that uses Kynurenic acid from Tocris? If so please let us know.

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